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4-hydroxycoumarin

Also Known As:

4-OH coumarin

Networked: 22 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        4-hydroxycoumarin: 22
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        4-Hydroxycoumarins: 2
        4-hydroxycoumarin: 22

Experts

1.	Salinas-Jazmín, Nohemí: 2 articles (04/2010 - 05/2008)
2.	Velasco-Velázquez, Marco A: 2 articles (04/2010 - 05/2008)
3.	Mendoza-Patiño, Nicandro: 2 articles (05/2008 - 08/2003)
4.	Carelli, Claudia: 1 article (11/2020)
5.	Fais, Paolo: 1 article (11/2020)
6.	Freni, Francesca: 1 article (11/2020)
7.	Moretti, Matteo: 1 article (11/2020)
8.	Morini, Luca: 1 article (11/2020)
9.	Vignali, Claudia: 1 article (11/2020)
10.	Bądziul, Dorota: 1 article (08/2020)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 08/15/2020 - "Therefore, the aim of the present study was to investigate for the first time the efficacy of osthole, umbelliferone, esculin, and 4-hydroxycoumarin, alone and in combination with Temozolomide, in the elimination of deadly brain tumors, anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM) cells via programmed death. "
2.	Brain Neoplasms (Brain Tumor) 08/15/2020 - "Therefore, the aim of the present study was to investigate for the first time the efficacy of osthole, umbelliferone, esculin, and 4-hydroxycoumarin, alone and in combination with Temozolomide, in the elimination of deadly brain tumors, anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM) cells via programmed death. "
3.	Astrocytoma (Pilocytic Astrocytoma) 08/15/2020 - "Therefore, the aim of the present study was to investigate for the first time the efficacy of osthole, umbelliferone, esculin, and 4-hydroxycoumarin, alone and in combination with Temozolomide, in the elimination of deadly brain tumors, anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM) cells via programmed death. "
4.	Inflammation (Inflammations) 12/28/2011 - "We expect that an efficient linear synthesis of 4-hydroxycoumarin derivatives and key fragments that are useful agents for the modulation of inflammation as well as inhibition of coagulation will be of practical use." 07/01/2008 - "This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation."
5.	Neoplasms (Cancer) 04/01/2008 - "Five new 4-hydroxycoumarin derivatives were tested for cytotoxic activity in two tumor cell lines--HL-60 and EJ. " 05/01/2014 - "In summary, this study has identified three novel coumarin derivatives that in comparison to 4-hydroxycoumarin have a higher efficiency to reduce cancer cell viability and trigger apoptosis and therefore may represent interesting novel drug candidates." 12/15/1986 - "Microsomes isolated from Lewis lung (LL) primary tumors raised in C57BL/6 mice have been shown to (i) contain a 4-hydroxycoumarin (warfarin)-sensitive cycle of vitamin K metabolism which is at least qualitatively similar to that of liver, and (ii) catalyze the incorporation of NaH14 CO3 into endogenous protein in a vitamin-K hydroquinone-dependent reaction to produce gamma-carboxyglutamate. "

Related Drugs and Biologics

1.	7-hydroxycoumarin (umbelliferone)
2.	coumarin
3.	Esculin (Aesculin)
4.	Temozolomide (Temodar)
5.	osthol (osthole)
6.	Glutathione (Reduced Glutathione)
7.	Coumarins
8.	Warfarin (Coumadin)
9.	Rodenticides
10.	Anticoagulants

Related Therapies and Procedures

1.	Therapeutics