davallialactone

from Davallia mariesii; structure given in first source

Also Known As:

1H,3H-Furo(3,4-c)oxepin-1-one, 3-(3,4-dihydroxyphenyl)-6-(2-(3,4-dihydroxyphenyl)ethenyl)-3a,4-dihydro-8-hydroxy-4-(2-oxopropylidene)-

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - davallialactone: 7

Experts

1.	Yun, Bong-Sik: 4 articles (11/2013 - 04/2011)
2.	Lee, Young-Hee: 3 articles (11/2013 - 04/2011)
3.	Yi, Ho-Keun: 3 articles (11/2013 - 04/2011)
4.	Lee, Nan-Hee: 2 articles (11/2013 - 04/2011)
5.	Paudel, Usha: 2 articles (11/2013 - 07/2013)
6.	Lee, In-Kyoung: 2 articles (08/2013 - 04/2011)
7.	Kim, Go-Eun: 1 article (11/2013)
8.	Song, Yong-Beom: 1 article (11/2013)
9.	Yu, Mi-Kyung: 1 article (11/2013)
10.	Gang, Gil-Tae: 1 article (08/2013)

Related Diseases

1.	Hyperuricemia 01/01/2023 - "This study showed that davallialactone significantly inhibits XO and has the potential to be developed into a novel medicine to prevent hyperuricemia and treat gout."
2.	Hyperglycemia 07/24/2013 - "The purpose of this study was to clarify whether davallialactone from mushroom extract affected the pathogenesis of hyperglycemia oxidative stress and the aging process in human diploid fibroblast (HDF) cells. "
3.	Gout 01/01/2023 - "This study showed that davallialactone significantly inhibits XO and has the potential to be developed into a novel medicine to prevent hyperuricemia and treat gout."
4.	Inflammation (Inflammations) 11/01/2013 - "Davallialactone reduces inflammation and repairs dentinogenesis on glucose oxidase-induced stress in dental pulp cells." 07/24/2013 - "Davallialactone from mushroom reduced premature senescence and inflammation on glucose oxidative stress in human diploid fibroblast cells." 04/01/2011 - "Reactive oxygen species removal activity of davallialactone reduces lipopolysaccharide-induced pulpal inflammation through inhibition of the extracellular signal-regulated kinase 1/2 and nuclear factor kappa b pathway." 04/01/2011 - "The antioxidant activity of davallialactone leads to inhibition of LPS-induced inflammation by blocking the extracellular signal-regulated kinase (ERK1/2) and nuclear factor kappa B (NF-κB) pathway, which decreases the expression of inflammatory molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule-1, matrix metalloproteinase-2, matrix metalloproteinase-9, inducible nitric oxide synthase, and cyclooxygenase-2. "
5.	Cardiotoxicity 01/01/2012 - "Davallialactone protects against adriamycin-induced cardiotoxicity in vitro and in vivo."

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Mitogen-Activated Protein Kinase 3
4.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
5.	Matrix Metalloproteinase 9 (Gelatinase B)
6.	Matrix Metalloproteinase 2 (Gelatinase A)
7.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
8.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	NF-kappa B (NF-kB)