centromere protein E

human centromere-associated protein required for progression from metaphase to anaphase; RefSeq NM_001813 (human); NM_173762 (mouse)

Also Known As:

CENP-E protein; CENPE protein, human; Cenpe protein, mouse; centromere protein E, 312kDa, human; centromere protein E, human; centromere protein E, mouse

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nuclear Proteins: 2678
    - Non-Histone Chromosomal Proteins: 44
      - centromere protein E: 8
  - Nucleoproteins: 1870
    - Non-Histone Chromosomal Proteins: 44
      - centromere protein E: 8

Experts

1.	Chen, Yuhong: 1 article (12/2021)
2.	Shi, Ke: 1 article (12/2021)
3.	Sun, Xiaodong: 1 article (12/2021)
4.	Wu, Jiali: 1 article (12/2021)
5.	Zhang, Jingfa: 1 article (12/2021)
6.	Zhu, Xinyue: 1 article (12/2021)
7.	Almacellas, Eugènia: 1 article (01/2021)
8.	Ambrosio, Santiago: 1 article (01/2021)
9.	Day, Charles: 1 article (01/2021)
10.	Mauvezin, Caroline: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 02/05/2019 - "The clinical trials emerged centromere protein E inhibitor GSK923295 as a promising anticancer drug, but its function in hepatocellular carcinoma (HCC) remain needs to be fully elucidated, especially as chemotherapy after hepatectomy for liver tumors. " 09/01/2020 - "Expression of the genes encoding the AT-Hook Containing Transcription Factor 1 (AHCTF1), the Cancer Susceptibility Candidate 5 (CASC5), the Centromere Protein C (CENPC), the Centromere Protein E (CENPE), the Centromere Protein F (CENPF), the NUF2 Component of NDC80 Kinetochore Complex (NUF2), the RAN-Binding Protein 2 (RANBP2), the Shugoshin-like 2 (SGOL2), the Structural Maintenance of Chromosomes 3 (SMC3), and the Spindle Apparatus Coiled-Coil Protein 1 (SPDL1) proteins were specifically associated with CB-EPCs. "
2.	Hepatocellular Carcinoma (Hepatoma) 02/05/2019 - "The clinical trials emerged centromere protein E inhibitor GSK923295 as a promising anticancer drug, but its function in hepatocellular carcinoma (HCC) remain needs to be fully elucidated, especially as chemotherapy after hepatectomy for liver tumors. "
3.	Chromosomal Instability (Chromosome Stability) 01/01/2021 - ": 3D: three-dimensional; APC/C: anaphase-promoting complex; ARL8B: ADP ribosylation factor like GTPase 8B; ATG: autophagy-related; BORC: BLOC-one-related complex; CDK: cyclin-dependent kinase; CENPE: centromere protein E; CIN: chromosomal instability; ConcA: concanamycin A; CQ: chloroquine; DAPI: 4,6-diamidino-2-penylinole; FTI: farnesyltransferase inhibitors; GFP: green fluorescent protein; H2B: histone 2B; KIF: kinesin family member; LAMP2: lysosomal associated membrane protein 2; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEF: mouse embryonic fibroblast; MTOR: mechanistic target of rapamycin kinase; PDS5B: PDS5 cohesin associated factor B; SAC: spindle assembly checkpoint; PLEKHM2: pleckstrin homology and RUN domain containing M2; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; ULK1: unc-51 like autophagy activating kinase 1; UPS: ubiquitin-proteasome system; v-ATPase: vacuolar-type H+-translocating ATPase; WAPL: WAPL cohesion release factor."
4.	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 01/01/2012 - "Among the genes in the turquoise module, COL5A2 (collagen, type V, alpha 2) could be regulated by PBX (pre-B-cell leukemia homeobox 1)1/2 and HOXB1(homeobox B1) transcription factors to be involved in the focal adhesion pathway; CENP-E (centromere protein E, 312kDa) by E2F4 (E2F transcription factor 4, p107/p130-binding); MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived [avian]) by PAX5 (paired box 5); and BCL-2 (B-cell CLL/ lymphoma 2) and IGFBP-6 (insulin-like growth factor binding protein 6) by GLI1. "
5.	Retinoblastoma (Glioblastoma, Retinal) 12/01/2021 - "Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma."

Related Drugs and Biologics

1.	GSK923295
2.	Kinesins
3.	Transcription Factors (Transcription Factor)
4.	Anaphase-Promoting Complex-Cyclosome
5.	Lysosomal-Associated Membrane Protein 2
6.	Farnesyltranstransferase (Farnesyltransferase)
7.	E2F Transcription Factors
8.	Green Fluorescent Proteins
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	Ubiquitin

Related Therapies and Procedures

1.	Hepatectomy
2.	Drug Therapy (Chemotherapy)