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HLA-DRB1 antigen (HLA DRB1)

Subscribe to New Research on HLA-DRB1 antigen

amino acid sequence in first source

Also Known As:

HLA DRB1; HLA DR B1*04; HLA-DRB1; HLA-DRB1*03; HLA-DRB1*0301; HLA-DRB1*0312; HLA-DRB1*0318; HLA-DRB1*0401; HLA-DRB1*0402; HLA-DRB1*0432; HLA-DRB1*0804; HLA-DRB1*090103*; HLA-DRB1*09012; HLA-DRB1*11011; HLA-DRB1*1112; HLA-DRB1*11272; HLA-DRB1*1137; HLA-DRB1*1139; HLA-DRB1*1202; HLA-DRB1*1212; HLA-DRB1*1437

Networked: 1599 relevant articles (32 outcomes, 225 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Alfredsson, Lars: 17 articles (05/2015 - 05/2007)
2.	Thomson, W: 17 articles (01/2014 - 04/2000)
3.	Padyukov, Leonid: 16 articles (05/2015 - 01/2004)
4.	Ramagopalan, Sreeram V: 16 articles (09/2013 - 09/2007)
5.	Ebers, George C: 16 articles (08/2010 - 10/2005)
6.	Thomson, Wendy: 15 articles (12/2015 - 02/2002)
7.	Klareskog, Lars: 14 articles (05/2015 - 01/2004)
8.	Ollier, William E R: 13 articles (04/2009 - 02/2002)
9.	Tokunaga, K: 12 articles (12/2015 - 04/2000)
10.	Ollier, W E: 12 articles (06/2012 - 04/2000)

Related Diseases

1.	Infection 11/01/2004 - "DRB11101/DQB10301 haplotype, which mainly favors the spontaneous clearance of HCV infection, was lower in HCC subjects than in controls, whereas HLA-DRB11104/DQB10301, was higher in NHL patients. " 12/01/2008 - "HLA DRB1 1101, DQB1 0301 and DRB1 1301/DQA1 0103 alleles were associated with clearance of HCV whereas DRB1 0301 was associated with chronic infection. " 06/01/2000 - "Our results suggest that HLA DRB101 appears to contribute to the spontaneous resolution of a primary HCV infection in the Irish population. " 01/01/2014 - "This study suggests that HLA-DRB11501 and DQB10602 alleles may influence the immune response to HPV16 infection and decrease the risk of ICC among Uighurs and Hans in Xinjiang, China. " 11/01/2012 - "This study examined the associations between the development of Kazakh ESCC and the determinant factors including HLA-DRB10901, 1501; DQB1*0301, 0602; high-risk HPV infection in the area of Xinjiang, China. "
2.	Rheumatoid Arthritis 01/01/2013 - "This study was performed to systematically summarize results on the association of HLA-DRB1 with rheumatoid arthritis (RA) in China. " 01/01/2013 - "The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. " 01/01/2013 - "In the present study, we found that PADI4 risk allele and HLA-DRB1 shared epitope are independent genetic risks for radiographic progression in Japanese rheumatoid arthritis patients. " 07/01/2012 - "HLA-DRB1 allelic groups were genotyped in 1,073 ACPA-positive RA patients from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study. " 06/01/2012 - "The aim of this study is to explore relationship between HLA-DRB1 alleles and the susceptibility and clinical features of rheumatoid arthritis (RA) in the south Tunisian population. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/01/1999 - "HLA-DRB10403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA10301-DQB10302/DQA10501-DQB10201 genotype." 03/01/2000 - "In conclusion, HLA-DRB1 0403 and -DQB1*0301 alleles in cis as well as protective DQ haplotypes in trans, confer dominant protection against IDDM in a German / Belgian population." 01/01/2013 - "In this study, for the first time, we investigated the influence of gender on the HLA-DRB1 and -DQB1 association with type 1 diabetes mellitus in Iranian patients in order to determine gender dependent HLA heterogeneity in Iranian T1D patients. " 04/01/2001 - "The aim of this study was to characterize HLA-encoded susceptibility to IDDM in Hungary and to identify whether HLA-DRB1/DQ-encoded susceptibility could account for the five times lower incidence of disease in Hungary compared with Finland. " 11/01/1999 - "The aim of the present study was to estimate the frequency of chosen HLA DRB1 gene alleles in patients with insulin-dependent diabetes mellitus and their first degree relatives in comparison with the healthy population in the north-eastern region of Poland. "
4.	Multiple Sclerosis 06/01/2011 - "To identify the contribution of HLA-DRB1 alleles to susceptibility or resistance to multiple sclerosis (MS) in Caucasians through a meta-analysis of non-family-based studies. " 06/01/2011 - "Relationship between HLA-DRB1 polymorphism and susceptibility or resistance to multiple sclerosis in Caucasians: a meta-analysis of non-family-based studies." 01/15/2011 - "Spinal cord involvement in multiple sclerosis: a correlative MRI and high-resolution HLA-DRB1 genotyping study." 12/01/2010 - "The aim of our study was to investigate the association of HLA-DRB1 and -DQB1 alleles with multiple sclerosis (MS) in a Tunisian population and their effect on age at onset and disease severity. " 10/01/2010 - "In all of these genes, in a study by the International Multiple Sclerosis Genetics Consortium, the classic MS risk locus, HLA-DRB1, stood out with remarkably strong statistical significance, but they also identified 12 other loci and/or genes associated with MS. However, all of these alleles have a very modest odds ratio and they explain approximately 3% of the variance in MS risk. "
5.	Arthritis (Polyarthritis) 08/12/1993 - "Maternal-fetal disparity in alleles of HLA- DRB1, DQA, and DQB occurred in 26 of 34 pregnancies characterized by remission or improvement (76 percent), as compared with 3 of 12 pregnancies characterized by active arthritis (25 percent) (odds ratio, 9.7; P = 0.003). " 04/01/1999 - "Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study." 05/01/2011 - "HLA-DRB1 alleles were investigated in 33 Iranian children with oligoarthritis and RF negative polyarthritis JIA and compared with 45 healthy controls. " 09/01/2010 - "Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 01 and/or 04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort." 05/01/2010 - "It was found that in children with So-JIA subset (P=0.023, OR=2.25) and polyarthritis JIA subset (P=0.034, OR=2.81), the allele HLA-DRB1*08 was expressed most commonly. "

Related Drugs and Biologics

1.	HLA-A Antigens (HLA-A)
2.	HLA-DRB1 antigen (HLA DRB1)
3.	HLA-DQB1 antigen (HLA DQB1)
4.	HLA-B Antigens (HLA-B)
5.	HLA-C Antigens (HLA-C)
6.	HLA-DQ Antigens (HLA-DQ)
7.	Antigens
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Antirheumatic Agents (DMARD)
10.	HLA DRB1 07 antigen

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Kidney Transplantation