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S-100 calcium-binding protein beta subunit

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a biomarker of neural tissue damage; stimulates glial cell proliferation; amino acid sequence has been determined

Also Known As:

NTP-S100beta; S-100b protein; S-100beta; S100 beta protein, human; S100 calcium binding protein, beta (neural), human; S100 protein, beta polypeptide, neural, mouse; S100 protein, beta polypeptide, rat; S100B protein, human; S100b protein; S100b protein, mouse; S100b protein, rat; S100beta protein; nerve tissue protein S 100, beta subunit; nerve tissue protein S 100b; neural protein S-100B; neurotrophic protein S100beta

Networked: 312 relevant articles (8 outcomes, 63 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Gazzolo, Diego: 13 articles (01/2015 - 02/2002)
2.	Michetti, Fabrizio: 9 articles (09/2006 - 02/2002)
3.	Esposito, Giuseppe: 6 articles (01/2015 - 09/2007)
4.	Psachoulia, Christina: 6 articles (10/2013 - 08/2004)
5.	Lituania, Mario: 6 articles (09/2006 - 02/2002)
6.	Marinoni, Emanuela: 6 articles (09/2006 - 02/2002)
7.	Cuomo, Rosario: 5 articles (01/2015 - 09/2007)
8.	Sarnelli, Giovanni: 5 articles (01/2015 - 09/2007)
9.	Steardo, Luca: 5 articles (01/2015 - 06/2008)
10.	Souza, Diogo O: 5 articles (12/2007 - 12/2004)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 04/01/1999 - "Recent reports on the use of a quantitative measurement of S100B protein for the detection of metastatic melanoma have yielded promising results. " 01/01/2009 - "Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694." 01/01/2007 - "S-100beta serum determination should be considered to be included in clinical trials that test adjuvant therapies in melanoma patients." 01/01/2007 - "High S-100beta levels (during therapy) showed a relation with positive lymph node status (p = 0.014), number of positive lymph nodes (p = 0.01), macroscopic lymph node involvement (p = 0.002) and second melanoma diagnosis at study entry (p = 0.001). " 01/01/2007 - "It was the aim of this study to analyze the clinical value of the determination of serum S-100beta protein in high-risk melanoma patients. "
2.	Brain Injuries (Brain Injury) 08/31/2001 - "The increased levels of S-100beta seen after brain injury and in certain neurological and psychiatric disorders may be considered as beneficial for brain recovery." 01/01/2010 - "The prognostic value of the temporal course of S100beta protein in post-acute severe brain injury: A prospective and observational study." 01/01/2006 - "The aim of the present study was to clarify, whether intravenous application of endotoxin results in neuropathological findings and increased blood levels of the S100B protein, which is a consolidated marker of brain injury. " 07/01/2003 - "The objective of this study was to obtain data to further define the extent of traumatic brain injury by using S-100B protein and standard noncontrast magnetic resonance imaging with added fluid-attenuated inversion recovery (FLAIR) and gradient echo sequence in children with normal head computed tomography. " 12/01/2000 - "This finding supports the results of previous studies suggesting the potential accuracy of S-100beta in the prediction of brain injury after cardiac surgery."
3.	Neoplasms (Cancer) 01/01/2003 - "Fifty-nine patients were included in this study; serum S-100B protein was measured using an immunoluminometric assay while the expression pattern in the primary tumor was determined by immunohistochemistry using an anti-S-100B monoclonal antibody. " 01/01/2010 - "Based on the three-dimensional structure of a carboxyl-terminal peptide of p53 in complex with the S100B protein, which is involved in regulation of the tumor suppressor activity, a model of wild type (WT) and mutant extreme CTD was developed by molecular modeling and molecular dynamics simulation. " 11/01/2005 - "In patients whose tumors are > 1 mm thickness, regular lymph node ultrasound examinations and determination of serum tumor marker S-100beta protein are commonly used by physicians in Germany. " 01/01/2004 - "[Role of S100B protein in neoplasms and other diseases]." 09/14/2001 - "S100B protein associates with both the p53 oligomerization domain (residues 325-355) and the extreme C terminus of the tumor suppressor p53 (residues 367-392). "
4.	Schizophrenia (Dementia Praecox) 06/01/1999 - "Our findings indicate that patients with schizophrenia may suffer ongoing structural damage to cells of the central nervous system, and that the concentration of S-100b protein in plasma may help to identify clinical subgroups in schizophrenia." 01/01/2001 - "Increased serum S100B protein in schizophrenia: a study in medication-free patients." 06/01/2010 - "REMOVAL: Elevated serum S100B protein in first-episode drug-naïve Chinese patients with schizophrenia. " 06/03/2013 - "These results reinforce the idea that the S100B protein is involved in the inflammatory response observed in many brain diseases, including schizophrenia. " 08/01/2013 - "While plasma levels of agmatine in patients with schizophrenia were significantly increased (p < 0.0001) compared to those of healthy individuals (control), there were no significant changes in the levels of S100B protein (p = 0.660). "
5.	Alzheimer Disease (Alzheimer's Disease) 06/01/2008 - "Previous studies suggest that levels of the astrocyte-derived S100B protein, such as those occurring in brain extra-cellular spaces consequent to persistent astroglial activation, may have a pathogenetic role in Alzheimer's disease (AD). " 01/01/2015 - "Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. " 03/29/2005 - "S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease and Down's syndrome. " 06/18/1999 - "The S100beta protein is overexpressed in the brain of patients with Alzheimer's disease and Down's syndrome and is able to induce apoptosis in neurons at high concentrations. " 01/01/2005 - "As for tau protein and beta-amyloid(1-42) (Abeta42), promising results for the diagnosis of Alzheimer's disease (AD) have been reported; we evaluated these markers and S-100B protein in cerebrospinal fluid (CSF), using a set of commercially available assays, of 71 patients with DLB, 67 patients with AD and 41 nondemented controls (NDC) for their differential diagnostic relevance. "

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