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CGP 31362

a synthetic analog of a lipoprotein fragment from the outer wall of gram negative bacteria; RN given refers to the Na-salt; RN for parent compound not available 5/91
Also Known As:
CGP-31362; N-hexadecanoyl-S-(2,3-didodecanoyloxypropyl)-cysteinyl-alanyl-isoglutaminyl-glycyl-taurine
Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1. Neoplasm Metastasis (Metastasis)
2. Renal Cell Carcinoma (Grawitz Tumor)
07/15/1991 - "We, therefore, designed experiments to evaluate the ability of a new macrophage activator, CGP 31362, a synthetic bacterial cell wall analogue, to cause regression of spontaneous lung metastases in mice whose primary renal adenocarcinoma was removed by nephrectomy. "
07/15/1991 - "Therapy of spontaneous lung metastasis of murine renal adenocarcinoma by systemic administration of liposomes containing the macrophage activator CGP 31362."
07/15/1991 - "Several lines of evidence indicate that in situ activation of macrophages was responsible for the therapeutic effects of MLV-CGP 31362: (a) macrophages harvested from the lungs of treated mice had significant tumoricidal activity against cultured renal carcinoma cells, (b) activated macrophages, as defined by the MRP-14 marker, were present in lung tumor nodules of treated mice but not untreated mice, and (c) the in situ activation of alveolar macrophages was consistent with the in vivo deposition of 60% of radiolabeled MLV-CGP 31362 liposomes in the lungs following i.v. injection. "
01/01/1991 - "We determined whether the intravenous administration of multilamellar vesicle liposomes (MLV) containing a lipopeptide analogue of a fragment from the cell wall of gram-negative bacteria (CGP 31362) can render BALB/c mouse alveolar macrophages tumoricidal in situ and reduce the incidence of spontaneous lung metastasis of syngeneic renal carcinoma (RENCA) cells. "
01/01/1991 - "In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362."
3. Neoplasms (Cancer)
4. Melanoma (Melanoma, Malignant)
5. Non-Hodgkin Lymphoma (Lymphosarcoma)

Related Drugs and Biologics

1. Liposomes (Liposome)
2. Lipopeptides
3. Interleukin-2 (IL2)
4. Interferon-gamma (Interferon, gamma)
5. Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6. Therapeutic Uses
7. Lipopolysaccharides
8. Acetylmuramyl-Alanyl-Isoglutamine

Related Therapies and Procedures

1. Therapeutics
2. Injections
3. Intravenous Administration
4. Nephrectomy
5. Immunotherapy