quinone methide

02/01/2023 - "Especially, ROS in tumor sites could trigger the immolation of CASDB to generate CA and quinone methide (QM). "
01/01/2023 - "Besides, quinone methide (QM) released by DQ targets the vulnerability of GSH; this effect, plus the increase of ROS, destroys the redox homeostasis and causes cancer cell death. "
01/01/2020 - "Under tumor stimuli condition, CA and quinone methide (QM) are quickly generated, which cooperatively induce strong oxidative stress, immunogenic tumor cell death (ICD), and activation of antigen presenting cells. "
01/14/2011 - "Oxidation to a reactive quinone methide is the mechanistic basis of many phenolic anti-cancer drugs. "
01/01/2005 - "Among these anti-tumor agents, one mechanism was involved in quinone methide intermediate. "

08/30/2023 - "Here, we find that pristimerin (PM), a quinone methide triterpenoid, is more effective in treating tendinopathy than the first-line drug indomethacin. "

01/01/2022 - "Two novel reagents, N-myristoylated Cbl-b inhibitory peptide (C14-Cblin) and celastrol, a quinone methide triterpene, are reported to be effective in preventing myotube atrophy. "

05/01/2014 - "Celastrol, a quinone methide triterpenoid, could induce apoptosis in pancreatic cancer cells. "
01/01/2021 - "In the present study, we aimed to describe the chemical synthetic lethal effects of the combination of gemcitabine and quinone-methide triterpenoid pristimerin in pancreatic cancer (PC) cells. "

01/01/2018 - "In the present study, we found that taxodione, a quinone methide diterpene isolated from Taxodium distichum, significantly induced apoptosis in human myelogenous leukemia-derived K562 cells, which were transformed by BCR-ABL. "
01/01/2019 - "Recently, we found that taxodione, a quinone methide diterpene isolated from a conifer, Taxodium distichum, significantly induced apoptosis in human myelogenous leukemia-derived K562 cells, which is positive for the bcr-abl gene. "