SK&F 105809

prodrug to SK&F 105561; structure given in first source; dual inhibitor of arachidonic acid metabolism

Also Known As:

6,7-dihydro-2-(4-(methylsulfinyl)phenyl)-3-(4-pyridyl)-5(1H)-pyrrolo(1,2-a)imidazole; SKF-105809

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - SK&F 105809: 6

Related Diseases

1.	Experimental Arthritis 01/01/1990 - "SK&F 105809 was also effective in inhibiting mouse collagen-induced arthritis and associated acute-phase reactant protein. "
2.	Craniocerebral Trauma (Head Injury) 04/01/1992 - "The present study was designed to determine the effect of a novel drug, SK&F 105809, a dual inhibitor of 5-LO and CO on cerebral edema formation after head injury in rats. "
3.	Brain Edema (Cerebral Edema) 04/01/1992 - "The present study was designed to determine the effect of a novel drug, SK&F 105809, a dual inhibitor of 5-LO and CO on cerebral edema formation after head injury in rats. " 04/01/1992 - "SK&F 105809 treated rats which received 30 mg/kg had significantly less brain edema, as measured by both gravimetry and water content, at 4 h after trauma. " 04/01/1992 - "The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat."
4.	Inflammation (Inflammations) 08/01/1992 - "SK&F 105809 is a structurally novel dual inhibitor of lipoxygenase and cyclooxygenase-mediated arachidonic acid (AA) metabolism, which has demonstrated antiinflammatory activity in rodent models of inflammation. " 01/01/1990 - "SK&F 105809 inhibited oedema and inflammatory-cell infiltration in arachidonic acid-induced inflammation in the mouse ear and rat paw as well as in carrageenan- and monosodium urate crystal-induced peritonitis. "
5.	Closed Head Injuries 04/01/1992 - "The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Acute-Phase Proteins (Acute-Phase Protein)
3.	Arachidonic Acid (Vitamin F)
4.	Lipoxygenase (Lipoxygenase-1)
5.	Cyclooxygenase Inhibitors
6.	Cytokines
7.	Eicosanoids
8.	Uric Acid (Urate)
9.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.	Indomethacin (Indometacin)