HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
SK&F 105809
prodrug to SK&F 105561; structure given in first source; dual inhibitor of arachidonic acid metabolism
Also Known As:
6,7-dihydro-2-(4-(methylsulfinyl)phenyl)-3-(4-pyridyl)-5(1H)-pyrrolo(1,2-a)imidazole; SKF-105809
Networked:
6
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
SK&F 105809: 6
Related Diseases
1.
Experimental Arthritis
01/01/1990 - "
SK&F 105809 was also effective in inhibiting mouse collagen-induced arthritis and associated acute-phase reactant protein.
"
2.
Craniocerebral Trauma (Head Injury)
04/01/1992 - "
The present study was designed to determine the effect of a novel drug, SK&F 105809, a dual inhibitor of 5-LO and CO on cerebral edema formation after head injury in rats.
"
3.
Brain Edema (Cerebral Edema)
04/01/1992 - "
The present study was designed to determine the effect of a novel drug, SK&F 105809, a dual inhibitor of 5-LO and CO on cerebral edema formation after head injury in rats.
"
04/01/1992 - "
SK&F 105809 treated rats which received 30 mg/kg had significantly less brain edema, as measured by both gravimetry and water content, at 4 h after trauma.
"
04/01/1992 - "
The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat.
"
4.
Inflammation (Inflammations)
08/01/1992 - "
SK&F 105809 is a structurally novel dual inhibitor of lipoxygenase and cyclooxygenase-mediated arachidonic acid (AA) metabolism, which has demonstrated antiinflammatory activity in rodent models of inflammation.
"
01/01/1990 - "
SK&F 105809 inhibited oedema and inflammatory-cell infiltration in arachidonic acid-induced inflammation in the mouse ear and rat paw as well as in carrageenan- and monosodium urate crystal-induced peritonitis.
"
5.
Closed Head Injuries
04/01/1992 - "
The mixed lipoxygenase/cyclooxygenase inhibitor SK&F 105809 reduces cerebral edema after closed head injury in rat.
"
Related Drugs and Biologics
1.
Proteins (Proteins, Gene)
2.
Acute-Phase Proteins (Acute-Phase Protein)
3.
Arachidonic Acid (Vitamin F)
4.
Lipoxygenase (Lipoxygenase-1)
5.
Cyclooxygenase Inhibitors
6.
Cytokines
7.
Eicosanoids
8.
Uric Acid (Urate)
9.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
10.
Indomethacin (Indometacin)