monatepil

structure in first source; RN refers to 1:1 maleate salt (AJ 2615)

Also Known As:

11-((4-(4-(4-fluorophenyl)-1-piperazinyl)butyryl)amino)-6,11-dihydrodibenzo(b,e)thiepin maleate; AJ 2615; AJ-2615; monatepil maleate; monatepil x maleate; monatepil, (+-) monatepil; monatepil, (R)-isomer; monatepil, (S)-isomer; 1-Piperazinebutanamide, N-(6,11-dihydrodibenzo(b,e)thiepin-11-yl)-4-(4-fluorophenyl)-, (Z)-2-butenedioate (1:1)

Networked: 15 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Floten, S H: 1 article (09/2001)
2.	He, G W: 1 article (09/2001)
3.	Liu, M H: 1 article (09/2001)
4.	Yang, Q: 1 article (09/2001)

Related Diseases

1.	Essential Hypertension 10/01/1994 - "The efficacy of monatepil, a new calcium antagonist, in the treatment of essential hypertension."
2.	Atherosclerosis 10/01/1994 - "However, the long-term effects of monatepil on the progression of atherosclerosis remain to be determined." 10/01/1994 - "In two studies on the same group of patients we evaluated noninvasive methods of assessing atherosclerosis and determined the effect of the new calcium channel-blocking agent monatepil on the progression of early atherosclerosis in humans. " 04/01/1996 - "These results indicate that AJ-2615 has the same potent antioxidative effect as probucol and suggest that a previously reported ability of AJ-2615 to inhibit the progression of atherosclerosis may be due to this antioxidative property. " 10/01/1994 - "Noninvasive quantitative evaluation of early atherosclerosis and the effect of monatepil, a new antihypertensive agent. " 10/01/1994 - "To determine the antiatherosclerotic effects of monatepil, we examined its effect on experimental atherosclerosis induced by feeding a high-cholesterol diet to monkeys, whose lipid metabolism resembles that of humans. "
3.	Hypertension (High Blood Pressure) 07/01/1993 - "The above results suggest that monatepil is a highly safe drug in the treatment of hypertension." 10/01/1994 - "The effects of monatepil, a new calcium antagonist with alpha 1-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in 86 patients with mild-to-moderate hypertension were examined in a randomized, open-label, multicenter (32 hospitals) study. " 10/01/1994 - "Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension."
4.	Hyperlipidemias (Hyperlipidemia) 11/01/1998 - "The mechanism of the prophylactic effect against hyperlipidemia by monatepil maleate was investigated in animal models. " 07/01/1997 - "These results suggest that ACAT-inhibiting effect of monatepil maleate plays an important role in the reduction of hyperlipidemia." 03/01/1994 - "1. The preventive effects of atherosclerosis and hyperlipidemia of monatepil ([(+-)-N-(6,11-dihydrodibenzo [b,e]thiepin-11-yl)-4-(4-fluorophenyl)-1-piperazine-butanamide+ + +]monomaleate , AJ-2615, CAS 103377-41-9), a new antihypertensive drug with potent calcium antagonistic and alpha 1-adrenoceptor blocking activities, were investigated in Japanese monkeys (Macaca fuscata) fed with a cholesterol-rich diet (2% cholesterol + 6% corn oil) and compared with those of prazosin. "
5.	Tachycardia (Tachyarrhythmias) 05/01/1993 - "These results suggested that AJ-2615 has potential as a long-acting (once daily dosage regimen) antihypertensive drug without causing a steep blood pressure fall and tachycardia." 07/01/1993 - "AJ-2615 (0.1 mg/kg per min for 2 min, i.v.) also suppressed atrial tachycardia induced by aconitine (0.01% aconitine solution) in rats. "

Related Drugs and Biologics

1.	Calcium
2.	Calcium Channels (Calcium Channel)
3.	Nitrendipine
4.	Lipoproteins (Lipoprotein)
5.	monatepil
6.	Diltiazem (Cardizem)
7.	Cholesterol
8.	Antihypertensive Agents (Antihypertensives)
9.	Prazosin (Minipress)
10.	Methacholine Chloride (Methacholine)

Related Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)