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kistrin

a 68 amino acid peptide isolated from Malayan pit viper venom; it inhibits the platelet GPIIb-IIIa receptor

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - kistrin: 7

Experts

1.	Alimenti, Elena: 1 article (06/2005)
2.	Della Morte, Rossella: 1 article (06/2005)
3.	Dipineto, Ludovico: 1 article (06/2005)
4.	Fioretti, Alessandro: 1 article (06/2005)
5.	Matteoli, Gianluca: 1 article (06/2005)
6.	Menna, Lucia Francesca: 1 article (06/2005)
7.	Pavone, Luigi Michele: 1 article (06/2005)
8.	Roperto, Sante: 1 article (06/2005)
9.	Scibelli, Antonio: 1 article (06/2005)
10.	Staiano, Norma: 1 article (06/2005)

Related Diseases

1.	Atherosclerosis 01/15/2000 - "Based on our results, Kistrin or peptides with similar pan-integrin selectivity patterns are prime candidates for use as anti-integrin antagonists in further studies of atherosclerosis and restenosis."
2.	Yersinia Infections 06/01/2005 - "In this study, three structurally distinct disintegrins (flavoridin, echistatin, kistrin) were used as molecular probes to further characterize the molecular mechanisms underlying Yersinia enterocolitica infection of host cells. "
3.	Bone Resorption 03/01/1994 - "In vitro, kistrin potently inhibited bone resorption by isolated rat osteoclasts cultured on slices of bovine bone, and kistrin also inhibited the attachment of 293 cells expressing recombinant human alpha v beta 3 to fibrinogen (IC50 = 1 nM). " 03/01/1994 - "Effects of kistrin on bone resorption in vitro and serum calcium in vivo." 03/01/1994 - "The effect of kistrin, an RGD-containing snake venom protein, on osteoclast-mediated bone resorption was investigated in vivo and in vitro. " 09/01/1997 - "Antibodies to alpha v beta 3, RGD peptides and RGD containing proteins such as echistatin, and kistrin were shown to inhibit bone resorption in vitro and in vivo. "
4.	Thrombosis (Thrombus) 11/01/1998 - "In vivo, kistrin and barbourin had significantly lower thrombus:muscle and pulmonary embolus:lung ratios in images compared with bitistatin. "
5.	Thrombocytopenia (Thrombopenia) 04/01/1990 - "Finally, kistrin injected at 1.0 mg/kg into rabbits reversibly inhibits platelet aggregation ex vivo over 30 min without induction of thrombocytopenia. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	echistatin
3.	Disintegrins
4.	Integrins
5.	Molecular Probes (Molecular Probe)
6.	Proteins (Proteins, Gene)
7.	Snake Venoms (Snake Venom)
8.	Fibrinolytic Agents (Antithrombotic Agents)
9.	Fibrinogen (Factor I)
10.	Calcium