formosanin C

diosgenin saponin from Paris formosana; structure given in first source

Also Known As:

Paris saponin II; diosgenin 3-O-alpha-rhamnopyranosyl-(1-4)-alpha-rhamnopyranosyl-(1-4)-(alpha-rhamnopyranosyl-(1-2))-beta-glucopyranoside; beta-D--Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-6-deoxy-alpha-L-mannopyranosyl-(1-4))-

Networked: 23 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gao, Wenyuan: 6 articles (11/2020 - 03/2011)
2.	Man, Shuli: 6 articles (11/2020 - 03/2011)
3.	Ma, Long: 4 articles (11/2020 - 10/2016)
4.	Su, Chun-Li: 3 articles (01/2022 - 03/2009)
5.	Cui, Jingxia: 3 articles (11/2020 - 08/2018)
6.	Liu, Zhen: 3 articles (10/2016 - 03/2011)
7.	Bai, Peng: 3 articles (05/2015 - 08/2012)
8.	Liu, Shanling: 3 articles (05/2015 - 08/2012)
9.	Wang, He: 3 articles (05/2015 - 08/2012)
10.	Xiao, Xue: 3 articles (05/2015 - 08/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 09/01/2022 - "Among the isolated compounds, paris saponin II (PSII) had the strongest cytotoxic effects against MCF-7 breast cancer cells. " 07/01/2021 - "Formosanin C promotes the curative efficacy of ultrasound-guided radiofrequency ablation in a mouse model of breast cancer." 07/01/2021 - "Radiofrequency ablation (RFA) is a less invasive approach compared with traditional surgical resection to treat malignancies, and the combination of RFA and chemotherapeutic agents, including formosanin C (FC), can synergistically improve the curative effects against breast carcinoma. "
2.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2012 - "In this study, we continue to establish the efficacy and mechanisms underlying the cytotoxic effects of the steroidal PS members, namely formosanin C (PSII) in ovarian cancer treatment. " 05/01/2015 - "Paris saponin II inhibits human ovarian cancer cell-induced angiogenesis by modulating NF-κB signaling." 08/01/2012 - "Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells." 04/01/2014 - "Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration."
3.	Lung Neoplasms (Lung Cancer) 01/01/2019 - "Formosanin C and PVII showed a synergistic antitumour effect on lung cancer cells. " 06/25/2016 - "Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells." 01/01/2019 - "The objective of this study is to investigate the synergistic mechanisms of polyphyllin VII (PVII) and formosanin C (FC) in lung cancer. " 08/01/2018 - "To investigate the synergistic mechanisms of Paris Saponin II (PSII) and Curcumin (CUR) in lung cancer. " 08/01/2018 - "Curcumin enhances the anti-cancer effects of Paris Saponin II in lung cancer cells."
4.	Neoplasms (Cancer) 05/01/2023 - "Formosanin C suppresses cancer cell proliferation and migration by impeding autophagy machinery." 06/25/2016 - "Paris Saponin II (PSII) has been shown anticancer activity against several cancer lines through the pro-apoptotic pathway. " 01/01/2023 - "Formosanin C (FC), a diosgenin derived from the rhizoma of Paris polyphylla var. yunnanensis, has shown potent anti-cancer activities against various cancer types. " 11/01/2020 - "Paris Saponin II (PSII) has been regarded as an effective and imperative component isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti-tumor effects on a variety of cancer. " 10/15/2016 - "In conclusion, polyphyllin I and formosanin C showed a synergistic anti-tumor effect on hepatocarcinoma cells. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/1990 - "Growth of subcutaneously transplanted MH134 mouse hepatoma was retarded by intraperitoneal treatment with 1-2.5 mg/kg of formosanin-C. " 07/29/2020 - "Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells." 01/01/1990 - "The activity of 5-fluorouracil against MH-134 mouse hepatoma was potentiated by intraperitoneal treatment with formosanin-C. "

Related Drugs and Biologics

1.	polyphyllin VII
2.	Saponins
3.	Diosgenin
4.	Caspase 2
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Matrix Metalloproteinases (MMPs)
7.	Lactic Acid (Lactate)
8.	Nitric Oxide (Nitrogen Monoxide)
9.	Lipopolysaccharides
10.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Radiofrequency Ablation
2.	Therapeutics
3.	Traditional Medicine (Folk Remedies)