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ONO-LB 457

LTB4 receptor antagonist; structure given in first source

Also Known As:

5-(2-(2-carboxyethyl)-3-(6-(4-methoxyphenyl)-5E-hexenyl)oxyphenoxy)valeric acid; ONO 4057; ONO-4057; ONO-LB-457

Networked: 8 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylpropionates
      - ONO-LB 457: 8

Experts

1.	El-Mas, Mahmoud M: 1 article (06/2018)
2.	Helmy, Maged W: 1 article (06/2018)
3.	Helmy, Mai M: 1 article (06/2018)
4.	Inomata, Yukihiro: 1 article (12/2009)
5.	Kobayashi, Eiji: 1 article (12/2009)
6.	Minamiguchi, Sachiko: 1 article (12/2009)
7.	Takeichi, Takayuki: 1 article (12/2009)
8.	Takeyoshi, Izumi: 1 article (12/2009)
9.	Tanaka, Koichi: 1 article (12/2009)
10.	Uemoto, Shinji: 1 article (12/2009)

Related Diseases

1.	Glomerulonephritis 02/01/1999 - "The LTB4 receptor antagonist ONO-4057 may thus be beneficial in the treatment of crescentic glomerulonephritis." 12/01/2005 - "This study was conducted to evaluate the role of LTB4 in glomerulonephritis, and to examine whether ONO-4057 moderated anti-Thy-1 nephritis. " 02/01/1999 - "To evaluate the role of leukotriene B4 (LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. "
2.	Nephritis 02/01/1999 - "The leukotriene B4 receptor antagonist ONO-4057 inhibits nephrotoxic serum nephritis in WKY rats." 12/01/2005 - "The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis." 12/01/2005 - "This study was conducted to evaluate the role of LTB4 in glomerulonephritis, and to examine whether ONO-4057 moderated anti-Thy-1 nephritis. " 02/01/1999 - "To evaluate the role of leukotriene B4 (LTB4) in glomerulonephritis, this study was conducted to examine whether ONO-4057, an LTB4 receptor antagonist, moderated nephritis caused by the injection of nephrotoxic serum (NTS) into Wistar-Kyoto rats. "
3.	Reperfusion Injury 12/07/2009 - "This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury." 12/07/2009 - "Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver."
4.	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/01/2009 - "In this study, we investigated whether ONO-4057, a LTB(4) receptor (BLTR) antagonist is capable of preventing bleomycin-induced pulmonary fibrosis. "
5.	Neutropenia 10/01/1992 - "In the in vivo study, ONO-4057 given orally, prevented LTB4-induced transient neutropenia or intradermal neutrophil migration in guinea pig (the dose causing 50% efficacy (ED50) = 25.6mg/kg or 5.3mg/kg). "

Related Drugs and Biologics

1.	Leukotriene B4 Receptors (Leukotriene B4 Receptor)
2.	Leukotriene B4
3.	Tacrolimus (Prograf)
4.	Bleomycin (Blenoxane)
5.	anti-Thy antibody
6.	Acetic Acid (Vinegar)
7.	Leukotriene D4
8.	Peroxidase (Myeloperoxidase)
9.	Indomethacin (Indometacin)
10.	Cyclophosphamide (Cytoxan)