ONO-NT 126

RN given refers to (1R-(1alpha,2alpha(Z),3alpha,4alpha)-isomer; RN for cpd without isomeric designation not avail 3/91; structure given in first source; thromboxane A2 antagonist

Also Known As:

6-(3-((((4-bromophenyl)sulfonyl)amino)methyl)bicyclo(2.2.1)hept-2-yl)-hex-5-enoic acid; ONO-NT-126

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - Bridged Bicyclo Compounds
        ONO-NT 126: 3
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - Bridged Bicyclo Compounds
    - ONO-NT 126: 3
Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Monounsaturated Fatty Acids: 676
      - ONO-NT 126: 3

Related Diseases

1.	Respiratory Hypersensitivity 07/01/1994 - "Thromboxane A2 (TXA2) receptor antagonists ONO-NT-126 and ONO-8809 inhibited the 13,14-dihydro-15-keto-PGF2 alpha-induced airway hyperresponsiveness to histamine, suggesting that the effect of 13,14-dihydro-15-keto-PGF2 alpha on bronchial hyperresponsiveness is likely to be mediated through TXA2." 10/01/1993 - "Thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner, but not the airway wall thickening induced by LTC4, suggesting that the effect of LTC4 on bronchial hyperresponsiveness is likely to be mediated through TXA2."
2.	Astrocytoma (Pilocytic Astrocytoma) 01/01/1992 - "TXA2-receptor antagonists (ONO NT-126, S-145, SQ29548 and ONO3708) concentration-dependently inhibited PIP2-specific PLase C activation by STA2, and they also inhibited [3H]SQ 29548 binding in human astrocytoma cells. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	ONO 8809
3.	Prostaglandin H2 Thromboxane A2 Receptors
4.	Leukotriene C4
5.	Thromboxane A2 (A2, Thromboxane)
6.	S 145
7.	SQ 29548
8.	STA 2