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prohibitin

a mitochondrial protein that has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle progression and in apoptosis; RefSeq NM_002634 (PHB, human); NM_031851 (Phb, rat); NM_007273 (PHB2, human); NM_007531 (Phb2, mouse)

Also Known As:

AtPHB3 protein, Arabidopsis; B cell receptor-associated protein 37; B cell receptor-associated protein 37, human; B-cell associated protein 37, human; BAP37 protein, human; BCAP37 protein, human; BCR-associated protein 37; BCR-associated protein 37, human; Bap37 protein, mouse; Bcap37 protein, mouse; PHB protein, human; PHB1 protein, S cerevisiae; PHB1 protein, human; PHB2 protein, C elegans; PHB2 protein, S cerevisiae; PHB2 protein, human; PHB3 protein, Arabidopsis; Phb protein, rat; Phb2 protein, mouse; Prohibitin 1 protein, C elegans; REA protein, human; Tc-Pro-1 protein, Toxocara canis; YGR132C protein, S cerevisiae; YGR231C protein, S cerevisiae; phb-1 protein, C elegans; prohibitin 2 protein, human; prohibitin 2 protein, mouse; prohibitin 2, C elegans; prohibitin 3, Arabidopsis; prohibitin protein, human; prohibitin protein, rat; prohibitin-like molecule protein, Toxocara canis; repressor of estrogen receptor activity protein, human

Networked: 211 relevant articles (3 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Transcription Factors: 20597
    - Repressor Proteins: 32
      - prohibitin: 211
  - DNA-Binding Proteins: 1111
    - Repressor Proteins: 32
      - prohibitin: 211

Experts

1.	Zhou, Tian-Biao: 10 articles (09/2014 - 01/2012)
2.	Theiss, Arianne L: 8 articles (01/2016 - 01/2007)
3.	Qin, Yuan-Han: 8 articles (01/2013 - 01/2012)
4.	Wang, Sheng: 6 articles (01/2008 - 06/2002)
5.	Lei, Feng-Ying: 5 articles (01/2013 - 01/2012)
6.	Chellappan, Srikumar: 5 articles (05/2009 - 07/2002)
7.	Zhao, Yan-Jun: 4 articles (02/2012 - 01/2012)
8.	Sitaraman, Shanthi V: 4 articles (05/2011 - 01/2007)
9.	Merlin, Didier: 4 articles (05/2011 - 01/2007)
10.	Li, Qi-Fu: 4 articles (03/2011 - 07/2008)

Related Diseases

1.	Colitis 05/01/2011 - "Genetic restoration of intestinal epithelial prohibitin 1 (PHB) levels during experimental colitis reduces the severity of disease through sustained epithelial antioxidant expression and reduced NF-κB activation. " 05/01/2011 - "Nanoparticle-based therapeutic delivery of prohibitin to the colonic epithelial cells ameliorates acute murine colitis." 07/01/2009 - "Our previous studies showed that prohibitin (PHB) levels are decreased during colitis and that cultured intestinal epithelial cells overexpressing PHB are protected from oxidative stress. " 05/15/2013 - "Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis." 11/15/2012 - "Prohibitin attenuates colitis-associated tumorigenesis in mice by modulating p53 and STAT3 apoptotic responses."
2.	Inflammation 07/01/2009 - "Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice." 08/01/2012 - "Vitamin D deficiency causes increase in the expression of TNF-α, thereby increasing inflammation and decreases the expression of VDR and prohibitin. " 08/01/2012 - "Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation." 05/15/2013 - "Expression of the mitochondrial protein prohibitin (PHB) is also decreased during intestinal inflammation. " 11/15/2012 - "Prohibitin 1 (PHB), a protein implicated in the regulation of proliferation, apoptosis, and transcription, is decreased in intestinal inflammation. "
3.	Ischemia 04/01/2014 - "Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction." 06/01/2015 - "miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury." 04/01/2014 - "Prohibitin overexpression protected CA1 neurons from transient forebrain ischemia. " 02/01/2012 - "Dingxin recipe ( ) prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses." 04/01/2014 - "Importantly, the improvement in CA1 neuronal viability translated into an improvement in hippocampal function: prohibitin expression ameliorated the spatial memory deficit induced by ischemia, assessed by the Y-maze test, and restored postischemic synaptic plasticity assessed by long-term potentiation, indicating that the neurons spared form ischemic damage were functionally competent. "
4.	Thrombosis (Thrombus) 04/01/2009 - "Among the most relevant results stand out the normalization by intensive ATV treatment of the expression of proteins that modulate inflammation and thrombosis such as protein disulfide isomerase ER60 (PDI), Annexin I, and prohibitin, or that have other protective effects as HSP-70. "
5.	Memory Disorders (Memory Loss) 04/01/2014 - "Importantly, the improvement in CA1 neuronal viability translated into an improvement in hippocampal function: prohibitin expression ameliorated the spatial memory deficit induced by ischemia, assessed by the Y-maze test, and restored postischemic synaptic plasticity assessed by long-term potentiation, indicating that the neurons spared form ischemic damage were functionally competent. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Disulfide-Isomerases
3.	Annexin A1
4.	3' Untranslated Regions (3' UTR)
5.	Tretinoin (Retinoic Acid)
6.	Mitochondrial Proteins (Mitochondrial Protein)
7.	RNA (Ribonucleic Acid)
8.	Glucose (Dextrose)
9.	Transcription Factors (Transcription Factor)
10.	Carbon Monoxide

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)