enadoline

kappa-opioid receptor agonist; RN given refers to cpd without isomeric designation; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer

Also Known As:

CAM 569; CAM 570; CAM-569; CAM-570; CI 977; CI-977; N-methyl-N-(7-(1-pyrolidinyl)-1-oxaspiro(4,5)dec-8-yl)-4-benzofuranacetamide; PD 129289; PD 129290; PD-129289; PD-129290; enadoline hydrochloride, (5R-(5alpha,7alpha,8beta)); enadoline, (5alpha,7alpha,8beta)-(+-)-isomer; enadoline, (5alpha,7alpha,8beta)-(-)-isomer

Networked: 25 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - enadoline: 25
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - enadoline: 25

Experts

1.	Onukwugha, Eberechukwu: 1 article (06/2022)
2.	Park, Jeong-Eun: 1 article (06/2022)
3.	Shah, Chintal H: 1 article (06/2022)
4.	Slejko, Julia F: 1 article (06/2022)
5.	Villalonga-Olives, Ester: 1 article (06/2022)
6.	Zafari, Zafar: 1 article (06/2022)
7.	Bergman, Jack: 1 article (12/2007)
8.	Gilman, Joanne P: 1 article (12/2007)
9.	Goldberg, Steven R: 1 article (12/2007)
10.	Graczyk, Zofi: 1 article (12/2007)

Related Diseases

1.	Pain (Aches) 03/01/1999 - "Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain." 10/01/1996 - "Enadoline 25 micrograms produced similar pain relief to that of morphine, although of shorter duration, and better than enadoline 15 micrograms or placebo. " 02/01/1996 - "Analgesic efficacy of the kappa-receptor agonist, enadoline, in dental surgery pain." 10/01/1996 - "Enadoline, a selective agonist of the kappa-opioid receptor, was studied for its analgesic efficacy in patients with pain after obstetric or gynecologic surgery. " 02/01/1996 - "To study the analgesic efficacy of enadoline, a selective agonist of the kappa-opioid receptor, a double-blind, randomized comparison was made of enadoline versus placebo and a combination of acetaminophen-codeine in patients with pain after surgical extraction of impacted molar teeth. "
2.	Parkinson Disease (Parkinson's Disease) 12/01/1999 - "2. The aim of this study was to investigate the potential anti-parkinsonian efficacy of the kappa-opioid receptor agonist, enadoline, and the alpha-adrenoreceptor agonist, clonidine, both alone or in combination, in the reserpine-treated rat model of Parkinson's disease. "
3.	Postoperative Pain 03/01/1999 - "This report describes and compares the activities of enadoline and morphine in a rat model of postoperative pain. " 10/01/1996 - "Analgesic efficacy of enadoline versus placebo or morphine in postsurgical pain." 10/01/1997 - "Spiradoline and enadoline have apparently been abandoned as potential analgesics because they induce dose-limiting central side-effects (i.e., dysphoria) in models of post-surgical pain. "
4.	Infarction (Infarctions) 03/27/1992 - "These results indicate that CI-977 is effective in reducing infarction in a model of focal cerebral ischaemia, and that the reduction in brain swelling occurs in parallel with the reduction in ischaemic damage." 11/26/1993 - "Treatment with CI-977 (0.3 mg/kg, s.c.) 30 min before and 30 min after occlusion of the MCA reduced the volume of infarction in the cerebral hemisphere (reduced by 27% when compared to vehicle; P < 0.05) and cerebral cortex (reduced by 32%; P < 0.05), despite a marked and sustained hypotension, with only minimal effect on damage in the caudate nucleus. " 07/01/1993 - "Enadoline produced dose-dependent reductions in the volumes of infarction and brain swelling; the greatest reductions were seen at 1.0 mg/kg plus 0.17 mg/kg/h in both infarction (reduced by 37.4% from controls) and swelling (reduced by 47.8%). " 03/27/1992 - "Treatment with CI-977 (0.03, 0.3 or 3 mg/kg), initiated 30 min prior to MCA occlusion (and at multiple times thereafter) produced dose-dependent reductions in the volumes of infarction and of brain swelling, with the most marked reductions being noted with CI-977 (0.3 mg/kg) in both infarction (reduced by 38% from controls; P less than 0.02) and swelling (reduced by 31%; P less than 0.002). "
5.	Brain Edema (Cerebral Edema) 03/27/1992 - "These results indicate that CI-977 is effective in reducing infarction in a model of focal cerebral ischaemia, and that the reduction in brain swelling occurs in parallel with the reduction in ischaemic damage." 07/01/1993 - "Enadoline produced dose-dependent reductions in the volumes of infarction and brain swelling; the greatest reductions were seen at 1.0 mg/kg plus 0.17 mg/kg/h in both infarction (reduced by 37.4% from controls) and swelling (reduced by 47.8%). " 03/27/1992 - "Treatment with CI-977 (0.03, 0.3 or 3 mg/kg), initiated 30 min prior to MCA occlusion (and at multiple times thereafter) produced dose-dependent reductions in the volumes of infarction and of brain swelling, with the most marked reductions being noted with CI-977 (0.3 mg/kg) in both infarction (reduced by 38% from controls; P less than 0.02) and swelling (reduced by 31%; P less than 0.002). " 03/27/1992 - "The effect of a novel, highly potent and selective kappa-opioid receptor agonist CI-977 upon ischaemic brain damage and brain swelling has been examined in a rat model of focal cerebral ischaemia. "

Related Drugs and Biologics

1.	kappa Opioid Receptors (kappa Opioid Receptor)
2.	Analgesics (Analgesic Drugs)
3.	Morphine (MS Contin)
4.	Reserpine (Serpasil)
5.	Clonidine (ST 155)
6.	codeine drug combination acetaminophen
7.	Opioid Analgesics (Opioids)
8.	TRK 820
9.	alpha-Methyltyrosine (Metirosine)
10.	mu Opioid Receptors (mu Opioid Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Gynecologic Surgical Procedures (Gynecologic Surgery)
3.	Drug Therapy (Chemotherapy)