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2-bromo-(diglutathion-S-yl)hydroquinone

Also Known As:

2-Br-(diGSyl)HQ; 2-Br-(diglutathion-S-yl)hydroquinone

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Glutathione: 14524
      - 2-bromo-(diglutathion-S-yl)hydroquinone: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Hydroquinones: 47
        2-bromo-(diglutathion-S-yl)hydroquinone: 4

Related Diseases

1.	Necrosis 10/01/1994 - "Mitochondria assumed a condensed configuration 2 hr after 2-Br-(diGSyl)HQ administration, but this was not followed by high-amplitude swelling prior to cell death and necrosis. " 12/03/1990 - "Administration of 2-bromo-(diglutathion-S-yl)hydroquinone (2-Br-[diGSyl]HQ) (10-30 mumol/kg; i.v.) to rats causes severe renal proximal tubular necrosis. " 10/01/1988 - "2-Bromo-(diglutathion-S-yl)hydroquinone [2-Br-(diGSyl)HQ] causes severe necrosis of the proximal renal tubules in the rat, elevations in blood urea nitrogen (BUN) and increased urinary excretion of protein, glucose, and lactate dehydrogenase. "
2.	Proteinuria 07/01/1994 - "2-Br-(diglutathion-S-yl)hydroquinone (2-Br-(diGSyl)HQ) is a potent nephrotoxicant, causing glucosuria, enzymuria, proteinuria, elevations in blood urea nitrogen, and severe histological alterations to renal proximal tubules at doses of 10-15 mumol/kg. In contrast, 2-Br-3-(glutathion-S-yl)hydroquinone (2-Br-3-(GSyl)HQ) is substantially less nephrotoxic than 2-Br-(diGSyl)HQ and requires a dose of at least 50 mumol/kg to cause modest elevations in blood urea nitrogen concentrations. "

Related Drugs and Biologics

1.	Urea (Carbamide)
2.	Nitrogen
3.	2-bromo-(diglutathion-S-yl)hydroquinone
4.	Proteins (Proteins, Gene)
5.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
6.	Glucose (Dextrose)