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16-fluoro-5-androsten-17-one
RN given refers to the (16alpha)-isomer; RN for cpd without isomeric designation not available 2/91; has antiproliferative effects on HIV-1 and reduces HIV-1 replication
Also Known As:
16 alpha-fluoro-5-androsten-17-one; 8354 compound
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Androstanes: 11
Androstenes: 5
16-fluoro-5-androsten-17-one: 7
Experts
1.
Pashko, Laura L
: 1 article (02/2002)
2.
Schwartz, Arthur G
: 1 article (02/2002)
Related Diseases
1.
Carcinogenesis
09/01/1991 - "
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.
"
11/01/1991 - "
In the two-stage skin tumorigenesis model in mice, topical application of the synthetic DHEA analog 16 alpha-fluoro-5-androsten-17-one, a more potent preventive agent than DHEA without the sex-hormonal side-effects of the parent steroid, markedly inhibited promotion of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated tumor development by 12-O-tetradecanoylphorbol-13-acetate (TPA).
"
06/01/1988 - "
Two synthetic steroids, 16 alpha-fluoro-5-androsten-17-one and 16 alpha-fluoro-5 alpha-androstan-17-one, which are more potent inhibitors of the above three processes in tumorigenesis and are also more effective than dehydroepiandrosterone in inhibiting skin papilloma development in the mouse, are more active in suppressing prostaglandin E2 induction by 12-O-tetradecanoyl-phorbol-13-acetate.
"
2.
Neoplasms (Cancer)
11/01/1991 - "
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation in mice by 16 alpha-fluoro-5-androsten-17-one and its reversal by deoxyribonucleosides.
"
01/01/1995 - "
We have developed a synthetic steroid, 16 alpha-fluoro-5-androsten-17-one, which does not demonstrate the androgenic or estrogenic activity of DHEA, yet retains the antiproliferative and cancer preventive activity of the native steroid.
"
11/01/1991 - "
In the two-stage skin tumorigenesis model in mice, topical application of the synthetic DHEA analog 16 alpha-fluoro-5-androsten-17-one, a more potent preventive agent than DHEA without the sex-hormonal side-effects of the parent steroid, markedly inhibited promotion of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated tumor development by 12-O-tetradecanoylphorbol-13-acetate (TPA).
"
09/01/1991 - "
The chemopreventive action of 40 and 80% maximum tolerated dose (MTD) levels of piroxicam, D,L-alpha-difluoromethylornithine (DMFO), 16 alpha-fluoro-5-androsten-17-one (DHEA analogue 8354), and ellagic acid (EA) administered in diet individually and in combination before and during initiation and postinitiation phases of azoxymethane-induced neoplasia of the intestine was studied in male F344 rats.
"
3.
Papilloma (Papillomatosis)
10/01/1989 - "
It is now shown that oral administration of the synthetic steroid 16 alpha-fluoro-5-androsten-17-one, which lacks the side-effects of DHEA treatment, to CD-1 mice inhibits 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation at both the initiation and promotion stage.
"
06/01/1988 - "
Two synthetic steroids, 16 alpha-fluoro-5-androsten-17-one and 16 alpha-fluoro-5 alpha-androstan-17-one, which are more potent inhibitors of the above three processes in tumorigenesis and are also more effective than dehydroepiandrosterone in inhibiting skin papilloma development in the mouse, are more active in suppressing prostaglandin E2 induction by 12-O-tetradecanoyl-phorbol-13-acetate.
"
4.
Body Weight (Weight, Body)
01/15/1991 - "
administered dehydroepiandrosterone (DHEA), DHEA plus N-(4-hydroxyphenyl)retinamide (4-HPR), or 16 alpha-fluoro-5-androsten-17-one (DHEA analogue 8354) was examined in rats treated with N-methyl-N-nitrosourea (MNU; 50 mg/kg body weight, i.v.) at 50 days of age.
"
5.
Arthritis (Polyarthritis)
02/01/2002 - "
Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one.
"
Related Drugs and Biologics
1.
Dehydroepiandrosterone (DHEA)
2.
Steroids
3.
anthracene
4.
Fenretinide
5.
Dinoprostone (PGE2)
6.
Piroxicam (Feldene)
7.
Methylnitrosourea (N-Methyl-N-nitrosourea)
8.
Ellagic Acid
9.
Deoxyribonucleosides
10.
Azoxymethane
Related Therapies and Procedures
1.
Chemoprevention
2.
Oral Administration