MACHO protocol

chemotherapy protocol consisting of the above cpds; used in treatment of stage IV B cell lymphoma and B cell acute lymphoblastic leukemia of childhood & for Burkitt's lymphoma

Also Known As:

LMB protocol

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACHO protocol: 9
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACHO protocol: 9
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MACHO protocol: 9
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        Phosphoramide Mustards: 5
        Cyclophosphamide: 25473
        MACHO protocol: 9
- Organophosphorus Compounds: 300
  - Phosphoramides: 8
    - Phosphoramide Mustards: 5
      - Cyclophosphamide: 25473
        MACHO protocol: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Cytidine: 535
        Cytarabine: 6662
        MACHO protocol: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Aminopterin: 248
        Methotrexate: 24010
        MACHO protocol: 9
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Cytidine: 535
      - Cytarabine: 6662
        MACHO protocol: 9
  - Arabinonucleosides: 1
    - Cytarabine: 6662
      - MACHO protocol: 9

Experts

1.	Sebban, C: 2 articles (12/2005 - 02/2000)
2.	Im, Ho Joon: 1 article (03/2022)
3.	Jeon, Woojung: 1 article (03/2022)
4.	Kang, Sunghan: 1 article (03/2022)
5.	Kim, Hyery: 1 article (03/2022)
6.	Koh, Kyung-Nam: 1 article (03/2022)
7.	Koh, Young Kwon: 1 article (03/2022)
8.	Belesso, Marcelo: 1 article (10/2018)
9.	Lage, Luís Alberto P C: 1 article (10/2018)
10.	Pereira, Juliana: 1 article (10/2018)

Related Diseases

1.	B-Cell Lymphoma (Lymphoma, B Cell) 07/01/2000 - "Improved outcome in childhood B-cell lymphoma with the intensified French LMB protocol." 07/01/2000 - "Intensive chemotherapy with a modified LMB protocol and modern supportive care result in a high cure rate of childhood B cell lymphoma even in patients with advanced disease."
2.	Burkitt Lymphoma (Burkitt's Lymphoma) 10/01/2018 - "Treatment outcomes of adult Burkitt lymphoma: results with a modified LMB protocol in Brazil and feasibility of outpatient administration." 01/01/2011 - "Treatment outcome of adult Burkitt Lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis." 11/01/2009 - "Treatment outcome of adult patients with Burkitt lymphoma: results using the LMB protocol in Korea." 12/01/2005 - "Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol." 01/01/1992 - "Treatment of poor prognosis Burkitt's lymphoma in adults with the Société Française d'Oncologie Pédiatrique LMB Protocol--a study of the Federation Nationale des Centres de Lutte Contre le Cancer (FNLCC)."
3.	Neoplasms (Cancer) 01/01/1992 - "Treatment of poor prognosis Burkitt's lymphoma in adults with the Société Française d'Oncologie Pédiatrique LMB Protocol--a study of the Federation Nationale des Centres de Lutte Contre le Cancer (FNLCC)."
4.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 02/01/2000 - "The LMB protocol is an intensive chemotherapy regimen which yields high survival rates in Burkitt's lymphoma (BL) and diffuse large cell lymphoma (DLCL) in children, as well as in primary cerebral DLCL (PCL) of adults. "
5.	Lymphoma (Lymphomas) 10/01/2012 - "Concomitantly with HAART, all children with extracerebral lymphoma received intensive chemotherapy according to LMB protocol, those with primary central nervous system lymphoma received high-dose methotrexate. "

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Rituximab (Mabthera)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Highly Active Antiretroviral Therapy (HAART)