A 68828

03/06/1992 - "Further optimization of one of these modified structures leads to A68828, a full ANP agonist which shows promise as a preventative agent against acute renal failure."
01/01/1992 - "We have recently reported that administration of the ANF analog A68828 improves renal function in an acute model of postischemic acute renal failure. "
01/01/1992 - "Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure."
06/01/1991 - "These data indicate that infusion of the reduced-sized analog of ANF, A68828, can significantly improve glomerular and tubular function in rats with acute renal failure induced by CP."
12/01/1990 - "Beneficial effect of the atrial natriuretic factor analog A68828 in postischemic acute renal failure."

01/01/1992 - "Acute renal failure was induced in male Sprague-Dawley rats (200-250 g) by complete occlusion of both renal arteries for 30 min. During the initial 60 min following ischemia, vehicle (0.1% BSA in saline), A68828 (10 micrograms/kg/min); dopamine (10 micrograms/kg/min); A68828 (10 micrograms/kg/min) plus dopamine (10 micrograms/kg/min); or ANF[1-28] (0.5 microgram/kg/min) were infused intravenously. "