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6-thiodihydroorotate

structure given in first source

Also Known As:

2-oxo-6-thioxohexahydropyrimidine-4-carboxylate; TDHO

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        Orotic Acid: 384
        6-thiodihydroorotate: 3
- Heterocyclic Acids
  - Orotic Acid: 384
    - 6-thiodihydroorotate: 3

Experts

1.	Kelley, R I: 1 article (08/2001)
2.	Okano, S: 1 article (08/2001)
3.	Seo, K W: 1 article (08/2001)
4.	Watanabe, T: 1 article (08/2001)

Related Diseases

1.	Malaria 05/03/1994 - "The reaction, N-carbamyl-L-aspartate-->L-dihydroorotate (CA-asp-->DHO) catalyzed by malarial dihydroorotase is inhibited by L-6-thiodihydroorotate (TDHO) in vitro (Ki = 6.5 microM), and TDHO, as the free acid or methyl ester, induces a major accumulation of CA-asp in malaria. "
2.	Leukemia 12/15/1990 - "TDHO methyl ester (25 microM) had only slight inhibitory effects upon the dihydroorotase reaction of de novo pyrimidine biosynthesis in growing leukemia cells, cells arrested in G2 + M phases of the cell cycle. " 12/15/1990 - "Using human CCRF-CEM leukemia cells growing in culture, TDHO and HDDP as the free acids have 50% inhibitory concentration (IC50) values of 32 microM and greater than 1000 microM, respectively, whereas for TDHO methyl ester, the IC50 value is 25 microM, and for HDDP dimethyl ester, the IC50 value is 21 microM. " 12/15/1990 - "At 250 microM TDHO methyl ester, analysis of cell extracts by high-performance liquid chromatography showed that after 4 h carbamyl aspartate had accumulated from undetectable levels to 760 microM, whereas UTP decreased from 580 to 110 microM and CTP from 350 to 86 microM, indicating inhibition of dihydroorotase in growing leukemia cells. "
3.	Chondrodysplasia Punctata (Stippled Epiphyses) 08/01/2001 - "Both the phenotypes and genes responsible for Tdho as well as Td are quite similar to those of human X-linked chondrodysplasia punctata (CDPX2)."

Related Drugs and Biologics

1.	Esters
2.	Dihydroorotase
3.	Aspartic Acid (Aspartate)
4.	Acids
5.	Uridine Triphosphate (UTP)
6.	Cytidine Triphosphate (CTP)
7.	Cell Extracts
8.	2- oxo- 1,2,3,6- tetrahydropyrimidine- 4,6- dicarboxylate
9.	pyrimidine
10.	4,5-dihydroorotic acid