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saintopin

structure given in first source; has topoisomerase II dependent DNA cleavage activity; from Paecilomyces

Also Known As:

5,12-Naphthacenedione, 1,3,8,10,11-pentahydroxy-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Benz(a)Anthracenes: 2
        saintopin: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Benz(a)Anthracenes: 2
    - saintopin: 2

Experts

1.	Verma, Rajeshwar P: 1 article (09/2006)

Related Diseases

1.

Neoplasms (Cancer)

05/15/1996 - "We established saintopin-resistant cell lines (KB/STP-1 and KB/STP-2) from human epidermoid cancer KB cells by stepwise exposure to increasing doses of the drug. "
05/15/1996 - "Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins."
09/01/2006 - "Quinone moieties are present in many drugs such as anthracyclines, daunorubicin, doxorubicin, mitomycin, mitoxantrones and saintopin, which are used clinically in the therapy of solid cancers. "

Related Drugs and Biologics

1.	Anthracyclines
2.	Mitomycin (Mitomycin-C)
3.	Doxorubicin (Adriamycin)
4.	Type I DNA Topoisomerases (Topoisomerase I)
5.	Daunorubicin (Cerubidine)
6.	quinone (benzoquinone)

Related Therapies and Procedures

1.	Therapeutics