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KB 5666
structure given in first source
Also Known As:
2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate; KB-5666; Quinazoline, 4-(pentyloxy)-2-(4-(2-propenyl)-1-piperazinyl)-, (E)-2-butenedioate (1:1)
Networked:
3
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
KB 5666: 3
Related Diseases
1.
Ischemia
11/01/1990 - "
KB-5666 (i.p.) also showed protective effects in a dose-dependent manner immediately after ischemia.
"
11/01/1990 - "
KB-5666 (3-50 mg/kg, i.v.) showed protective effects against neuronal death of the CA1 subfield 5 min before ischemia, immediately or 1 hr after ischemia, but not 4 hr after ischemia.
"
01/01/1991 - "
In the morphological study, KB-5666, 10 and 50 mg/kg, i.v., 5 min before ischemia, protected against ischemic neuronal damage to the hippocampal CA1 subfield following 5 min of bilateral carotid artery occlusion in a dose-dependent manner.
"
11/01/1990 - "
These histologic, immunohistochemical and receptor-autoradiographic data indicate that KB-5666 protects the brain from both cellular and functional consequences of ischemia.
"
05/02/1991 - "
We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro.
"
2.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
05/02/1991 - "
In a rat with middle cerebral artery occlusion, administration of KB-5666 (3 and 10 mg/kg) immediately after ischemia prevented the formation of brain edema in the cortex and ameliorated the histological neuronal damage in the same area, but failed to do so in the striatum.
"
3.
Brain Edema (Cerebral Edema)
05/02/1991 - "
These results indicate that KB-5666 is a potential inhibitor of lipid peroxidation that could possibly prevent ischemic complications such as formation of brain edema and neuronal damage.
"
05/02/1991 - "
We studied the effects of 2-(allyl-1-piperazinyl)-4-n-amyloxyquinazoline fumarate (KB-5666) on brain edema and histological neuronal damage in rats with focal ischemia and on lipid peroxidation in brain homogenates and brain mitochondria in vitro.
"
05/02/1991 - "
In a rat with middle cerebral artery occlusion, administration of KB-5666 (3 and 10 mg/kg) immediately after ischemia prevented the formation of brain edema in the cortex and ameliorated the histological neuronal damage in the same area, but failed to do so in the striatum.
"
Related Drugs and Biologics
1.
Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
2.
Pentobarbital (Nembutal)