LY 178210

5-hydroxytryptamine receptor agonist; structure given in first source; LY 228729 is the (-)-isomer; LY 228730 is the (+)-isomer

Also Known As:

LY 228729; LY 228730; LY-178210; LY-228729; LY-228730; LY228729; Benz(cd)indole-6-carboxamide, 4-(dipropylamino)-1,3,4,5-tetrahydro-

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Ergot Alkaloids: 208
    - Ergolines: 109
      - LY 178210: 4
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Ergolines: 109
      - LY 178210: 4

Related Diseases

1.	Vomiting 12/11/1997 - "LY228729 appears to be a broad spectrum antiemetic agent that is effective against the anticipatory, the acute and the delayed stages of emesis induced by oncolytic agents." 12/11/1997 - "When used as a rescue therapy in a separate group of pigeons, LY228729 (0.32 mg/kg, i.m.) prevented further emetic episodes when it was administered after vomiting had already been induced by cyclophosphamide. " 11/01/1995 - "In the pigeon, LY228729 totally abolished vomiting induced by fully emetic doses of cisplatin (10 mg/kg), ipecac (3 ml/kg), emetine (10 mg/kg), and a 5-HT3 agonist, m-(chlorophenyl)-biguanide (1.25 mg/kg). "
2.	Shock 11/01/1996 - "5HT(1A) agonists, 8-OH DPAT, buspirone and LY228729 produced the typical large increases in punished responding in procedure one, were substantially less effective when shock levels were increased in procedure two, and produced differential results which were likely due to the schedule in procedure three. "
3.	Motion Sickness (Airsickness) 10/01/1993 - "In the preclinical efficacy models, LY228729 suppressed motion sickness responses in cats; decreased ejaculatory latency and the increased copulatory efficiency and rate in rats and increased punished responding at lower doses than it lowered unpunished responding in rats. " 10/01/1993 - "Collectively, these results indicate that LY228729 is potent 5-HT1A agonist with bioavailability properties sufficient for clinical evaluation and with efficacy in preclinical models of anxiety, sexual disorders and motion sickness. "

Related Drugs and Biologics

1.	Buspirone (Buspar)
2.	Antiemetics
3.	Emetics
4.	Serotonin 5-HT3 Receptor Agonists
5.	Serotonin 5-HT1 Receptor Agonists
6.	Ipecac (Syrup of Ipecac)
7.	Emetine
8.	Cyclophosphamide (Cytoxan)
9.	Cisplatin (Platino)
10.	Biguanides

Related Therapies and Procedures

1.	Therapeutics