luteolin-7-glucoside

has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum

Also Known As:

4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-; cinaroside; cynaroside; galuteolin; luteolin-7-O-beta-D-glucopyranoside; luteolin-7-O-glucoside; luteolin-7-O-monoglucoside; luteolin-7-beta-D-glucoside; luteoloside; nephrocizin; nephrocizine

Networked: 59 relevant articles (9 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	He, Huan: 2 articles (01/2022 - 06/2018)
2.	He, Ming: 2 articles (01/2022 - 06/2018)
3.	Yin, Dong: 2 articles (01/2022 - 06/2018)
4.	Chen, Hang: 2 articles (11/2021 - 07/2021)
5.	Feng, Jiafan: 2 articles (11/2021 - 07/2021)
6.	Liu, Zhijun: 2 articles (11/2021 - 07/2021)
7.	Lu, Dezhao: 2 articles (11/2021 - 07/2021)
8.	Wang, Cui: 2 articles (11/2021 - 07/2021)
9.	Chen, Mu-Kuan: 2 articles (10/2021 - 01/2020)
10.	Chuang, Yi-Ching: 2 articles (10/2021 - 01/2020)

Related Diseases

1.	Sepsis (Septicemia) 07/01/2021 - "The findings provide crucial information with regard to therapeutic efficacy of cynaroside in the treatment of sepsis." 11/15/2021 - "In the present study, we aimed to investigate whether cynaroside exerted protective effects against sepsis and its potential mechanism. " 11/15/2021 - "Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization." 04/24/2021 - "RDN and its effective constituent luteoloside exhibited a significant protective effect against sepsis, which were potential candidate drugs for treatment of sepsis. " 07/01/2021 - "In this study, cynaroside, a flavonoid compound, promoted macrophage phenotypic transition from pro-inflammatory M1 to anti-inflammatory M2, and mitigated sepsis-associated liver inflammatory damage. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2019 - "The purpose of this study was to investigate the protective effect of luteoloside on cerebral ischemia and explore its potential mechanism. " 12/01/2020 - "Galuteolin Inhibited Autophagy for Neuroprotection Against Transient Focal Cerebral Ischemia in Rats." 01/01/2019 - "Collectively, our findings suggested that luteoloside played a crucial neuroprotective role by inhibiting NF-κB signaling in focal cerebral ischemia in rats. " 01/01/2019 - "In addition, our data suggested that luteoloside might be an effective treatment for cerebral ischemia and other neurological disorders." 01/01/2019 - "Middle cerebral artery occlusion (MCAO) was performed to investigate the effects of luteoloside on cerebral ischemia-reperfusion (I/R). "
3.	Inflammation (Inflammations) 11/15/2021 - "Taken together, the data claims cynaroside ameliorated systematic inflammation and multi-organ injury dependent on Nrf2/HO-1 pathway in septic mice." 12/01/2020 - "Cynaroside protected hPDL cells from LPS-induced damage and inflammation via inhibition of NF-κB activation. " 10/21/2020 - "Galuteolin suppresses proliferation and inflammation in TNF-α-induced RA-FLS cells by activating HMOX1 to regulate IKKβ/NF-κB pathway." 10/01/2018 - "Luteoloside Protects the Uterus from Staphylococcus aureus-Induced Inflammation, Apoptosis, and Injury." 01/01/2016 - "Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model."
4.	Mouth Neoplasms (Oral Cancer) 01/01/2020 - "The study findings showed that in addition to preventing cell proliferation, luteolin-7-O-glucoside caused a significant reduction in oral cancer cell migration and invasion. " 01/01/2020 - "The study identifies luteolin-7-O-glucoside as a potential anti-cancer candidate that can be utilized clinically for improving oral cancer prognosis." 01/01/2020 - "This is the first study to demonstrate the luteolin-7-O-glucoside inhibits cell migration and invasion by regulating MMP-2 expression and extracellular signal-regulated kinase pathway in human oral cancer cell. " 01/01/2020 - "In the present study, we aimed at evaluating the effects of a natural plant flavonoid, luteolin-7-O-glucoside, on oral cancer cell migration and invasion. " 01/01/2020 - "Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway."
5.	Hepatitis B 07/01/2023 - "Recent studies suggest resveratrol, vitamin E, lactoferrin, selenium, curcumin, luteolin-7-O-glucoside, moringa extracts, chlorogenic acid, and epigallocatechin-3-gallate may be beneficial for patients with hepatitis B. "

Related Drugs and Biologics

1.	Chlorogenic Acid
2.	Vitamin E
3.	Selenium
4.	Lactoferrin
5.	Curcumin
6.	Resveratrol
7.	epigallocatechin gallate (epigallocatechin-3-gallate)
8.	Palmitic Acid (Hexadecanoic Acid)
9.	Flavonoids
10.	Luteolin

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Intraperitoneal Injections