ceramide kinase

catalyzes the conversion of ceramide to ceramide 1-phosphate; calcium dependent

Also Known As:

CERK protein, human; CERKL protein, human; Cerk protein, mouse; LK4 protein, human; ceramide kinase protein, human; ceramide kinase, mouse; lipid kinase 4 protein, human

Networked: 62 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        ceramide kinase: 62

Experts

1.	Murayama, Toshihiko: 5 articles (05/2022 - 01/2010)
2.	Nakamura, Hiroyuki: 5 articles (05/2022 - 01/2010)
3.	Gomez-Muñoz, Antonio: 5 articles (01/2022 - 06/2013)
4.	Marfany, Gemma: 5 articles (01/2021 - 01/2004)
5.	Gonzàlez-Duarte, Roser: 5 articles (01/2020 - 01/2004)
6.	Tanaka, Ai: 3 articles (05/2022 - 01/2018)
7.	Gomez-Larrauri, Ana: 3 articles (01/2022 - 02/2016)
8.	Ouro, Alberto: 3 articles (01/2022 - 06/2013)
9.	Chalfant, Charles E: 3 articles (01/2022 - 02/2007)
10.	Trueba, Miguel: 3 articles (01/2021 - 06/2013)

Related Diseases

1.	Virus Diseases (Viral Diseases) 01/01/2022 - "In this study, we demonstrated that zebrafish ceramide kinase-like (CERKL) mediates protection against viral infection via two distinct mechanisms: stabilization of TANK-binding kinase 1 (TBK1) through impairing K48-linked ubiquitination and degradation of spring viremia of carp virus (SVCV) P protein by dampening K63-linked ubiquitination, resulting in an improvement of the host immune response and a decline in viral activity in epithelioma papulosum cyprini (EPC) cells. "
2.	Viremia 01/01/2022 - "In this study, we demonstrated that zebrafish ceramide kinase-like (CERKL) mediates protection against viral infection via two distinct mechanisms: stabilization of TANK-binding kinase 1 (TBK1) through impairing K48-linked ubiquitination and degradation of spring viremia of carp virus (SVCV) P protein by dampening K63-linked ubiquitination, resulting in an improvement of the host immune response and a decline in viral activity in epithelioma papulosum cyprini (EPC) cells. "
3.	Carcinoma (Carcinomatosis) 01/01/2022 - "In this study, we demonstrated that zebrafish ceramide kinase-like (CERKL) mediates protection against viral infection via two distinct mechanisms: stabilization of TANK-binding kinase 1 (TBK1) through impairing K48-linked ubiquitination and degradation of spring viremia of carp virus (SVCV) P protein by dampening K63-linked ubiquitination, resulting in an improvement of the host immune response and a decline in viral activity in epithelioma papulosum cyprini (EPC) cells. "
4.	Insulin Resistance 05/07/2012 - "Ceramide kinase deficiency improves diet-induced obesity and insulin resistance." 03/15/2015 - "By the end of phase (1), the biochemical analysis showed a positive response of the levels of C-peptide and modified homeostatic model assessment of insulin resistance; also increased levels of the serum ceramide kinase enzyme, coupled with improved cognitive functions tests. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2023 - "Inhibition of Ceramide Kinase Is Effective against Cisplatin-Resistant Ovarian Cancer Cells by Regulating Ceramide and C1P Levels." 01/01/2023 - "This work investigated the expression and function of ceramide kinase (CerK), a lipid kinase that regulates central bioactive sphingolipids, in ovarian cancer, as well as the therapeutic potential of targeting CERK. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphotransferases (Kinase)
3.	erucylphosphocholine
4.	Enzymes
5.	Ceramides
6.	Cisplatin (Platino)
7.	Cuprizone
8.	C-Peptide
9.	Cytokines
10.	Interleukin-4 (Interleukin 4)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)