prolinedithiocarbamate (PDTC)

11/01/2010 - "These results unravel a previously unrecognized mechanism by which PDTC and related compounds could confer cellular protection against inflammation through HSF1-induced expression of heat shock response genes."
09/05/2014 - "These results demonstrate that PDTC presents antioxidant and anti-inflammatory effects in vitro, which line up well with the PDTC inhibition of UVB irradiation-induced skin inflammation and oxidative stress in mice. "
11/01/2013 - "Our results suggest that intranasal PDTC provides neuroprotection possibly via reducing inflammation and oxidative stress. "
06/01/2012 - "These results suggest that PDTC protects against kidney inflammation of SLE at least in part via NF-κB and MAPK signaling pathways induction, and that inhibitory action on anti-dsDNA may be associated with the protective mechanism of PDTC. "
08/20/2008 - "However, the effects of PDTC against airway inflammation and its underlying mechanisms have not been reported. "

07/10/2015 - "In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). "
02/01/2015 - "This prompted us to study the cytomorphological features of PDTC and assess features of distinction from differentiated thyroid carcinoma (DTC) and medullary thyroid carcinoma (MTC). "
01/01/2013 - "DH-14-3 cells may be useful for investigating the biological features of PDTC and will contribute to the therapeutic study of thyroid cancer."
05/01/2012 - "The purpose of the present study was to explore the role of REGγ in poorly differentiated thyroid carcinoma (PDTC). "
11/01/2015 - "Ch22q LOH is preferentially associated with RAS mutations in papillary and in poorly differentiated thyroid cancer (PDTC). "

07/15/2010 - "The present study characterizes the development of fibrosis in the mdx musculature, and determines the fibrolytic efficacy of PDTC and UDCA. "
06/01/2012 - "Our results indicate that LPS induces MCP-1 mainly through activating NF-κB and its downstream MAPK, and that such effect was inhibited by PDTC, suggesting the efficacy of PDTC in preventing kidney fibrosis in lupus-prone mice. "
07/01/2015 - "Myocardial fibrosis and CAV in the PDTC group were significantly attenuated compared with the CsA group (P < .01). "
12/01/2014 - "By quantitative whole-slide image analysis, PDTC did not alter interstitial CD68+ cell accumulation, interstitial fibrosis, or renal cell proliferation in LPK rats at week 11. "
08/01/2009 - "The histological changes such as alveolitis and fibrosis in PQ + PDTC group were slighter than those in PQ group. "

06/01/2012 - "Our data show that a significant reduction in flap necrosis can be achieved by intravenous application of PDTC."
10/02/2012 - "In conclusion, these results suggest that Hg(2+)/PDTC complex-induced oxidative stress causes macrophage cell death via both apoptosis and necrosis. "
06/01/2012 - "The PDTC nonischemic group had a significantly lower flap necrosis than the ischemic control group (p  =  .005). "
06/01/2010 - "However, PDTC increased H(2)O(2) formation and necrosis, resulting in an overall increase in IR-induced cell death. "
02/01/2008 - "Treatment of BE(2)C cells with the Cu(PDTC)2 complex caused the S-phase arrest of cell cycle progression, cellular apoptosis, and necrosis, and increased the expression of p53 protein. "

05/15/2000 - "Moreover, these new results suggest that such protective effects of alpha-tocopherol and PDTC on cerebral vascular cells might be useful therapeutic tools in cerebral vascular injury associated with low [Mg(2+)](o) and accumulation of [Ca(2+)](i)."
07/01/2001 - "Moreover, these new results suggest that such protective effects of alpha-tocopherol and PDTC on cerebral vascular cells might be useful therapeutic tools in prevention and amelioration of cerebral vascular injury and stroke in alcoholics."
07/01/2001 - "The aim of the present study was to determine whether potent antioxidants [alpha-tocopherol and pyrrolidine dithiocarbamate (PDTC)] can prevent or ameliorate intracellular Mg(2+) ([Mg(2+)](i)) depletion associated with cerebral vascular injury induced by alcohol. "
05/15/2000 - "The aim of the present study was to determine whether potent antioxidants [alpha-tocopherol and pyrrolidine dithiocarbamate (PDTC)] can prevent or ameliorate intracellular Ca(2+) ([Ca(2+)](i)) overload associated with cerebral vascular injury induced by low extracellular free Mg(2+) ([Mg(2+)](o)). "
01/15/2003 - "The recent findings, that antioxidants (Vitamin E and pyrrolidine dithiocarbamate (PDTC)) prevent intracellular Ca(2+) ([Ca(2+)](i)) overload in cerebral vascular smooth muscle cells, induced by alcohol, demonstrate indirectly that ROS formation is related to cerebral vascular injury. "