salvianolic acid A

a nootropic depside from Salvia miltiorrhizia

Also Known As:

(+)-salvianolic acid A; benzenepropanoic acid, alpha-(((2E)-3-(2-((1E)-2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-dihydroxy-, (alphaR)-; dan phenolic acid A

Networked: 148 relevant articles (25 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Lactates: 140
      - salvianolic acid A: 148
  - Carbocyclic Acids
    - Cinnamates: 48
      - Caffeic Acids: 15
        salvianolic acid A: 148

Experts

1.	Du, Guanhua: 10 articles (01/2022 - 10/2011)
2.	Zhang, Li: 8 articles (01/2020 - 10/2011)
3.	Du, Guan-Hua: 5 articles (09/2022 - 06/2016)
4.	Yang, Haiguang: 5 articles (01/2022 - 10/2011)
5.	Yang, Xiuying: 5 articles (01/2020 - 10/2011)
6.	Zhao, Yan: 5 articles (05/2018 - 05/2012)
7.	Yan, Yu: 5 articles (03/2017 - 06/2016)
8.	Zhang, Sen: 4 articles (09/2022 - 03/2021)
9.	Zhang, Wen: 4 articles (09/2022 - 11/2016)
10.	Gu, Qing: 4 articles (07/2021 - 01/2017)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 01/01/1997 - "Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice." 01/01/1995 - "[Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice]." 07/01/2021 - "Salvianolic acid A alleviated inflammatory response mediated by microglia through inhibiting the activation of TLR2/4 in acute cerebral ischemia-reperfusion." 11/01/2016 - "[Salvianolic acid A alleviate the brain damage in rats after cerebral ischemia-reperfusion through Nrf2/HO-1 pathway]." 01/01/1997 - "Salvianolic acid A (Sal A) at the dosage of 3 and 10 mg.kg-1 i.v. could improve the impaired memory function induced by cerebral ischemia-reperfusion as shown in step down and step through tests. "
2.	Reperfusion Injury 01/01/2018 - "Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway." 03/01/2019 - "Anti-apoptotic effects and mechanisms of salvianolic acid A on cardiomyocytes in ischemia-reperfusion injury." 01/01/2018 - "Salvianolic Acid A Protects Against Oxidative Stress and Apoptosis Induced by Intestinal Ischemia-Reperfusion Injury Through Activation of Nrf2/HO-1 Pathways." 01/01/2018 - "Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats." 11/01/2011 - "Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury."
3.	Cardiotoxicity 02/02/2019 - "Salvianolic acid A (Sal A) is a major effective component in treating ATO-induced cardiotoxicity. " 01/01/2018 - "The cardio-protective effect of salvianolic acid A (Sal A) against ATO cardiotoxicity has been reported. " 12/01/2022 - "Protective effects of salvianolic acid A on clozapine-induced cardiotoxicity in zebrafish." 01/01/2017 - "This study aimed to investigate whether Salvianolic acid A (Sal A) conferred cardiac protection against Arsenic trioxide (ATO)-induced cardiotoxicity in H9c2 cells by inhibiting MAPK pathways activation. " 01/01/2018 - "Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity."
4.	Atherosclerosis 01/01/2022 - "Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis." 02/28/2020 - "Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats." 04/01/2023 - "Salvianolic acid A (SalA) is a water-soluble phenolic acid that benefits atherosclerosis. " 05/23/2023 - "Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells." 04/01/2023 - "Salvianolic acid A alleviates atherosclerosis by inhibiting inflammation through Trc8-mediated 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation."
5.	Non-alcoholic Fatty Liver Disease 01/01/2020 - "Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice." 01/01/2016 - "New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats."

Related Drugs and Biologics

1.	salvianolic acid B
2.	Antioxidants
3.	Arsenic Trioxide (Trisenox)
4.	3,4-dihydroxyphenyllactic acid
5.	tanshinone
6.	Polyphenols
7.	Sirtuin 1
8.	hydroxysafflor yellow A
9.	Monocrotaline
10.	phenolic acid

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Ligation
4.	Intraperitoneal Injections
5.	Drug Therapy (Chemotherapy)