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3-hydroxy-10,11-dihydroquinidine

structure given in first source

Also Known As:

LNC 834; LNC-834; Cinchonan-3,9-diol, 10,11-dihydro-6'-methoxy-, (9S)-, sulfate (1:1) (salt)

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198

Related Diseases

1.	Ventricular Tachycardia 09/01/1990 - "In the PES model, LNC-834 (3 mg of base/kg) suppressed ventricular tachycardia (VT) in 33% (2/6) of the dogs tested: none of the six quinidine-treated animals displayed suppression of VT at cumulative doses of 0.3 to 30 mg of base/kg. In PES dogs, inducible and noninducible, mortality was less with LNC-834 treatment than with quinidine [9% (1/11) and 36% (4/11), respectively]. "
2.	Ventricular Fibrillation 09/01/1990 - "The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias. "
3.	Infarction (Infarctions) 09/01/1990 - "The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias. "
4.	Hypotension (Low Blood Pressure) 09/01/1990 - "Although no treatment significantly affected the intrinsic heart rate in VFT dogs, both LNC-834 and quinidine produced significant hypotension; however, LNC-834 caused less hypotension than did quinidine at equal doses. "
5.	Cardiac Arrhythmias (Arrythmia) 09/01/1990 - "Comparison of the effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine in canine models of arrhythmia." 09/01/1990 - "The effects of intravenous LNC-834, a new antiarrhythmic agent, and quinidine sulfate were evaluated and compared in 24-h infarction, programmed electrical stimulation (PES), and ventricular fibrillation threshold (VFT) canine models of cardiac arrhythmias. "

Related Drugs and Biologics

1.	Quinidine (Chinidin)