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nitro- bis(2,4- pentanedionato)(bis(2- chloroethyl)amine)cobalt(III)
structure given in first source
Also Known As:
Co(BCA)
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ketones: 2618
Pentanones
nitro-bis(2,4-pentanedionato)(bis(2-chloroethyl)amine)cobalt(III): 1
Organometallic Compounds: 64
nitro-bis(2,4-pentanedionato)(bis(2-chloroethyl)amine)cobalt(III): 1
Related Diseases
1.
Neoplasms (Cancer)
11/01/1990 - "
In addition, in the FSaIIC murine fibrosarcoma, Co(BCA) produced a tumor growth delay of 9.4 days at 75 mg/kg i.p.
"
2.
Leukemia L1210
11/01/1990 - "
In mice bearing the L1210 leukemia i.p., Co(BCA) had a broad range of therapeutically effective dosage and produced a greater than 60-day increase in life span at a dose 20-fold less than was lethally toxic.
"
3.
Fibrosarcoma
11/01/1990 - "
In addition, in the FSaIIC murine fibrosarcoma, Co(BCA) produced a tumor growth delay of 9.4 days at 75 mg/kg i.p.
"
4.
Hyperthermia
11/01/1990 - "
These results indicate that Co(BCA) has significant antineoplastic effects in vitro and in vivo and interacts positively with both radiation and mild hyperthermia.
"
11/01/1990 - "
Hyperthermia (42 degrees C, 1 h) increased the slope of the concentration-dependent survival curve for Co(BCA) but not for Co(Py) in normally oxygenated EMT6 cells.
"
Related Drugs and Biologics
1.
Antineoplastic Agents (Antineoplastics)
2.
nitro- bis(2,4- pentanedionato)(pyridine)cobalt(III)