poliovirus receptor

an ortholog of mouse Tage4; used by poliovirus to bind and enter the cell; RefSeq NM_006505 (human)

Also Known As:

CD155 protein; CD155 protein, human; HVED protein, human; NECL5 protein, human; PVR protein, human; TAGE4 protein, human; nectin-like-5 protein, human; poliovirus receptor, human; poliovirus receptors; receptor, poliovirus

Networked: 141 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Virus Receptors: 342
        poliovirus receptor: 141

Experts

1.	Gromeier, Matthias: 10 articles (01/2021 - 07/2004)
2.	Takai, Yoshimi: 7 articles (03/2018 - 08/2004)
3.	Ikeda, Wataru: 6 articles (06/2007 - 08/2004)
4.	Bigner, Darell D: 4 articles (01/2021 - 07/2004)
5.	Koike, Satoshi: 4 articles (01/2016 - 03/2004)
6.	Nagata, Noriyo: 4 articles (01/2016 - 03/2004)
7.	Fujito, Tsutomu: 4 articles (06/2007 - 08/2004)
8.	Kajita, Mihoko: 4 articles (06/2007 - 10/2005)
9.	Minami, Yukiko: 4 articles (06/2007 - 08/2004)
10.	Shibuya, Akira: 3 articles (11/2021 - 02/2006)

Related Diseases

1.	Infections 10/15/1996 - "Greater than 90% of monocytes express the poliovirus receptor but only 6% of these cells are susceptible to poliovirus infection, making this a good system to study blocks to poliovirus replication. " 01/01/2020 - "They cause severe systemic infections by using signaling lymphocytic activation molecule (SLAM) and poliovirus receptor-like 4 expressed on immune and epithelial cells, respectively, as receptors. " 11/01/2018 - "Differences in the expression of CXADR cell receptor did not correlate with susceptibility to infection and replication of Coxsackie B virus, but complete inactivation of CXADR gene and poliovirus receptor gene (PVR) led to loss of the sensitivity to Coxsackie B5 and poliovirus, respectively. " 09/15/2005 - "One such virus, poliovirus (PV), is an extremely lytic RNA virus that requires the expression of CD155, the poliovirus receptor (PVR), for infection. " 01/20/2005 - "Murine L20B cells expressing human poliovirus receptor responded to the infection by both CPE and apoptosis concurrently. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/2021 - "This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). " 12/01/2005 - "Expression of poliovirus receptor-related proteins PRR1 and PRR2 in acute myeloid leukemia: first report of surface marker analysis, contribution to diagnosis, prognosis and implications for future therapeutical strategies." 01/01/2021 - "Abbreviations: AML: Acute myeloid leukemia; pAML: newly diagnosed AML; rAML: relapse AML; lrAML: AML in remission; HD: healthy donor; PB: peripheral blood; BM: bone marrow; TIGIT: T-cell immunoreceptor with Ig and ITIM domains; PD-1: Programmed cell death protein 1; CD73: ecto-5'-nucleotidase; CD39: ectonucleoside triphosphate diphosphohydrolase 1; ATP: adenosine triphosphate; ADO: adenosine; CD127: interleukin-7 receptor; CAR-T cell: chimeric antigen receptor T cell; TCF-1: transcription factor T-cell factor 1; TOX: Thymocyte selection-associated high mobility group box protein; NFAT: nuclear factor of activated T cells; NA: Naïve; CM: Central Memory; EM Effector Memory; EMRA: Terminal Effector Memory cells; FMO: Fluorescence minus one; PVR: poliovirus receptor; PVRL2: poliovirus receptor-related 2; IFN-γ: Interferon-γ; IL-2: interleukin-2; MCF: multiparametric flow cytometry; TNFα: Tumornekrosefaktor α; RT: room temperature."
3.	Paraproteinemias (Monoclonal Gammopathy) 01/01/2020 - "Here we analyzed the expression of TIGIT and its ligands poliovirus receptor (PVR) and nectin-2 in the bone marrow (BM) of patients with monoclonal gammopathies and the efficacy of TIGIT blockade activating antimyeloma immunity. "
4.	Cleft Lip (Harelip) 01/01/2009 - "To study the relationship of nonsyndromic cleft lip and/or palate (NSCL/P) and poliovirus receptor-related 1 exon3 (PVRL1exon3) polymorphisms in Han People of Jiangzhe area. " 01/01/2009 - "[Relationship of nonsyndromic cleft lip and/or palate and poliovirus receptor-related 1 exon 3 polymorphisms in Han people of Jiangzhe area]." 06/01/2008 - "Study of the poliovirus receptor related-1 gene in Thai patients with non-syndromic cleft lip with or without cleft palate." 11/01/2010 - "Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate." 10/01/2005 - "The aim of this study was to determine the sequence changes of the Cleft Lip and Palate Transmembrane Protein 1 (CLPTM 1) and Poliovirus Receptor Related 1 (PVRL 1) genes in patients with non-syndromic complete clefts of lip, alveolus and palate and to correlate these findings with clinical features. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Analysis of poliovirus receptor, CD155 expression in different human colorectal cancer cell lines: Implications for poliovirus virotherapy." 01/01/2021 - "We used quantitative real-time polymerase chain reaction (RT-qPCR) and western blot to detect the expression levels of lncRNA KCNQ1OT1 and the CD155 protein in colorectal cancer (CRC) tissues and cell lines. " 04/19/2016 - "Because colorectal cancer cells often acquire resistance to the molecular-targeted therapies and alternative treatments are called for, in this study, we evaluated the oncolytic activity against colorectal cancer cells of a recombinant measles virus (rMV-SLAMblind), which is blind to signaling lymphocytic activation molecule (SLAM) and infects target cells via nectin-4/poliovirus receptor-related 4 protein. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nectins
3.	Ligands
4.	Interferons
5.	Programmed Cell Death 1 Receptor
6.	T Cell Transcription Factor 1
7.	Toll-Like Receptors (Toll-Like Receptor)
8.	Interleukin-7 (Interleukin 7)
9.	5'-Nucleotidase (5' Nucleotidase)
10.	Interleukin-2 (IL2)

Related Therapies and Procedures

1.	Molecular Targeted Therapy
2.	Immunotherapy
3.	Therapeutics
4.	Radiotherapy
5.	Intraperitoneal Injections