duocarmycin SA

structure similar to CC-1065 and yatakemycin, composed of a pyrrolo-indole plus an indole; isolated from Streptomyces

Also Known As:

(+)-duocarmycin SA; Cyclopropa(c)pyrrolo(3,2-e)indole-6-carboxylic acid, 1,2,4,5,8,8a-hexahydro-4-oxo-2-((5,6,7-trimethoxy-1H-indol-2-yl)carbonyl)-, methyl ester, (7bR)-

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Duocarmycins: 63
        duocarmycin SA: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Duocarmycins: 63
        duocarmycin SA: 8

Experts

1.	Schuberth, Ingrid: 3 articles (01/2009 - 05/2008)
2.	Tietze, Lutz F: 3 articles (01/2009 - 05/2008)
3.	Tietze, L F: 2 articles (01/2011 - 07/2001)
4.	Krewer, Birgit: 2 articles (01/2009 - 05/2008)
5.	Schuster, Heiko J: 2 articles (01/2009 - 06/2008)
6.	Boger, Dale L: 1 article (01/2018)
7.	Boyle, Kristopher E: 1 article (01/2018)
8.	Vazquez, Marcelo: 1 article (01/2018)
9.	Wroe, Andrew: 1 article (01/2018)
10.	Chen, N: 1 article (01/2011)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2001 - "A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs." 06/15/2008 - "The synthesis and biological evaluation of novel prodrugs based on the cytotoxic antibiotic duocarmycin SA (1) for a selective treatment of cancer using a prodrug monotherapy (PMT) are described. " 01/01/2011 - "Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA." 01/22/2009 - "The synthesis and biological evaluation of novel prodrugs for use in the antibody directed enzyme prodrug therapy (ADEPT) of cancer based on the cytotoxic antibiotic duocarmycin SA (1) are described. " 05/01/2008 - "2 was designed as a detoxified analogue of the highly cytotoxic natural antibiotic duocarmycin SA (1) for the use in a targeted prodrug monotherapy of cancers expressing cholecystokinin (CCK-B)/gastrin receptors. "
2.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1995 - "Three duocarmycins, KW-2189, DU-86 and duocarmycin SA, were active against the cisplatin (CDDP)-resistant human non-small cell lung cancer cell lines PC-9/CDDP and PC-14/CDDP, and the multidrug-resistant human small cell lung cancer cell line H69/VP. "
3.	Sarcoma 180 03/01/1997 - "New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2018 - "Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/1995 - "Three duocarmycins, KW-2189, DU-86 and duocarmycin SA, were active against the cisplatin (CDDP)-resistant human non-small cell lung cancer cell lines PC-9/CDDP and PC-14/CDDP, and the multidrug-resistant human small cell lung cancer cell line H69/VP. "

Related Drugs and Biologics

1.	Prodrugs
2.	Anti-Bacterial Agents (Antibiotics)
3.	Enzymes
4.	Cholecystokinin B Receptor
5.	Protons (Proton)
6.	Glycosides
7.	Galactosidases
8.	Cisplatin (Platino)
9.	Cholecystokinin (Pancreozymin)
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)