proinsulin-like growth factor II

01/01/1994 - "Serum from patients with extrapancreatic tumor hypoglycemia (EPTH) contains elevated levels of big (pro) IGF II which disappears after successful removal of the tumor. "
06/15/1993 - "Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing."
12/01/1992 - "Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia?"
07/01/1992 - "Measurement of derivatives of proinsulin-like growth factor-II in serum by a radioimmunoassay directed against the E-domain in normal subjects and patients with nonislet cell tumor hypoglycemia."
03/01/2011 - "Increased levels of IGF-II precursors ("big" and pro-IGF-II) have been reported in the circulation of nonislet cell tumor patients and have been proposed to exert greater or different effects than mature IGF-II. However, most studies have not defined which version is being investigated, and the relative activation of the IR and IGF-IR by IGF-II precursors has not been delineated. "

02/08/2023 - "This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II. Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. "
12/01/2003 - "Hypoglycemia associated with big insulin-like growth factor II produced during development of malignant fibrous histiocytoma."
10/01/1998 - "Acinar cell carcinoma of the pancreas associated with hypoglycemia: involvement of "big" insulin-like growth factor-II."
12/01/1995 - "Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia."
01/01/1994 - "Serum from patients with extrapancreatic tumor hypoglycemia (EPTH) contains elevated levels of big (pro) IGF II which disappears after successful removal of the tumor. "

12/01/2005 - "In obese subjects, serum free and total IGF-II are increased, and we therefore investigated the impact of obesity and diet on serum pro-IGF-II. Non-diabetic, obese subjects (n = 34) with a body mass index (BMI) of 38.9 +/- 0.5 kg/m2 were subjected to 8 weeks with very low calorie diet (800 kcal/day) followed by 12 weeks with a weight-stabilizing diet. "
12/01/2005 - "Cross-sectional and longitudinal correlation analyses showed that pro-IGF-II was closer and more consistently associated with IGF-I than IGF-II. This study demonstrates that pro-IGF-II is reduced in obesity, in contrast to mature IGF-II. This indicates a hitherto unrecognized link between nutrition and pro-IGF-II. In addition, our data indicate that pro-IGF-II is regulated independently of mature IGF-II."

10/01/1990 - "Abnormal processing of pro-IGF-II in patients with hepatoma and in some hepatitis B virus antibody-positive asymptomatic individuals."
12/01/1995 - "Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia."
01/01/2016 - "Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report."
06/01/1998 - "We report a 22-yr-old male patient with chronic hepatitis B and a large, well differentiated hepatoma who developed episodes of symptomatic fasting hypoglycemia, which were caused by paraneoplastic secretion of unprocessed "big" insulin-like growth factor-II. Initially, the patient presented with normal liver function, which deteriorated during the clinical course. "
10/01/1990 - "Because an increased percentage of IGF-II in serum of patients with hypoglycemia who have other tumors is present as partially processed pro-IGF-II ("big" IGF-II), we passed sera of patients with hypoglycemia and patients with euglycemia with hepatomas through acidic Bio-Gel P-60 columns. "

01/01/2016 - "Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report."
07/01/2005 - "Non-islet cell tumor hypoglycemia (NICTH) results from the hypersecretion of pro-IGF-II by a large, usually mesenchymal tumor. "
02/08/2023 - "Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. "