AFDX 384

structure given in first source

Also Known As:

5,11-dihydro-11-(((2-(2-((dipropylamino)methyl)-1-piperidinyl)ethyl)amino)carbonyl)-6H-pyrido(2,3-b)(1,4)-benzodiazepin-6-one methanesulfonate; AF-DX 384; 11H-Pyrido(2,3-b)(1,4)benzodiazepine-11-carboxamide, N-(2-(2-((dipropylamino)methyl)-1-piperidinyl)ethyl)-5,6-dihydro-6-oxo-, monomethanesulfonate

Networked: 11 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        Pirenzepine: 520
        AFDX 384: 11

Experts

1.	Dean, Brian: 2 articles (04/2016 - 12/2015)
2.	Scarr, Elizabeth: 2 articles (04/2016 - 12/2015)
3.	Dean, B: 2 articles (08/2009 - 03/2000)
4.	Huang, Xu-Feng: 2 articles (01/2007 - 09/2005)
5.	Zavitsanou, Katerina: 2 articles (01/2007 - 05/2005)
6.	Gibbons, Andrew Stuart: 1 article (04/2016)
7.	Jeon, Won Je: 1 article (04/2016)
8.	Chen, Wei J: 1 article (12/2015)
9.	Lai, Chi-Yu: 1 article (12/2015)
10.	Thomas, Natalie: 1 article (12/2015)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/30/2007 - "No difference was observed for [(3)H]AF-DX 384 binding between the schizophrenia and control groups. " 09/15/2005 - "A tendency toward decreased [(3)H]AF-DX 384 binding density (34%, P=0.09) was also observed in schizophrenia patients compared with controls. " 05/15/2005 - "Using quantitative autoradiography we measured [(3)H]AF-DX 384 binding in the anterior cingulate cortex of 15 schizophrenia, 15 bipolar, 15 major depression and 15 control cases. " 01/01/1999 - "The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia." 03/01/2000 - "Studies using tissue obtained at autopsy suggest that changes in cholinergic neurons could be important in the pathology of schizophrenia.1-4 We have previously reported a decrease in [3H]pirenzepine binding5 and [3H]AF-DX 384 binding6 to caudate-putamen (CP) from subjects who had schizophrenia. "
2.	Major Depressive Disorder (Major Depressive Disorders) 08/01/2009 - "[3H]AFDX-384 binding was decreased in BA 46 in both bipolar disorder (p<0.01) and major depressive disorder (p<0.05). " 04/01/2016 - "Compared with controls, [(3)H]AF-DX 384 binding was lower in BA 24 and BA 46 in bipolar disorders and major depressive disorders, while CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding was only lower in BA 24. " 04/01/2016 - "We measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine. "
3.	Bipolar Disorder (Manic Depressive Psychosis) 08/01/2009 - "[3H]AFDX-384 binding was decreased in BA 46 in both bipolar disorder (p<0.01) and major depressive disorder (p<0.05). " 04/01/2016 - "Compared with controls, [(3)H]AF-DX 384 binding was lower in BA 24 and BA 46 in bipolar disorders and major depressive disorders, while CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding was only lower in BA 24. " 04/01/2016 - "We measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine. "
4.	Cognitive Dysfunction 08/01/1997 - "The effect of AFDX 384 on acetylcholine release and behaviour in the old rats offers further support to a relationship between the age-related cholinergic hypofunction and cognitive impairment and indicates the blockade of presynaptic muscarinic receptors as a possible selective target for therapeutic strategies aimed at improving age-associated memory deficits."
5.	Thiamine Deficiency 08/01/1995 - "In order to further evaluate this possibility, quantitative autoradiographic procedures using [3H]quinuclidinyl benzilate (for total muscarinic binding sites), [3H]pirenzepine (for muscarinic M1 sites) and [3H]AF-DX 384 (for muscarinic M2 sites) were performed at early (presymptomatic) and late (symptomatic) stages of thiamine deficiency induced in rats by administration of the central thiamine antagonist, pyrithiamine. "

Related Drugs and Biologics

1.	Pirenzepine
2.	Cholinergic Agents (Cholinergics)
3.	Muscarinic M2 Receptor
4.	Muscarinic Antagonists
5.	GABA-A Receptors (GABA(A) Receptor)
6.	Muscimol
7.	Ligands
8.	Thiamine (Aneurin)
9.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
10.	Quinuclidinyl Benzilate