kifunensine

inhibitor of the glycoprotein processing mannosidase I; from actinomycete Kitasatosporia kifunense 9482; structure given in first source; RN given refers to (5R-(5alpha,6beta,7alpha,8alpha,8aalpha))-isomer; RN for cpd without isomeric designation not avail 10/90

Also Known As:

FR 900494; FR-900494; imidazo(1,2-a)pyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - kifunensine: 10

Experts

1.	Eylmann, Kathrin: 2 articles (11/2019 - 01/2018)
2.	Legler, Karen: 2 articles (11/2019 - 01/2018)
3.	Milde-Langosch, Karin: 2 articles (11/2019 - 01/2018)
4.	Oliveira-Ferrer, Leticia: 2 articles (11/2019 - 01/2018)
5.	Rossberg, Maila: 2 articles (11/2019 - 01/2018)
6.	Schmalfeldt, Barbara: 2 articles (11/2019 - 01/2018)
7.	Bakhos-Douaihy, Dalal: 1 article (12/2021)
8.	Demaretz, Sylvie: 1 article (12/2021)
9.	Frachon, Nadia: 1 article (12/2021)
10.	Kömhoff, Martin: 1 article (12/2021)

Related Diseases

1.	Glycogen Storage Disease Type II (Pompe's Disease) 10/31/2018 - "This study proposed a rice cell-based glycoengineering strategy using two different mannosidase inhibitors, kifunensine (KIF) and swainsonine (SWA), to increase Man7/8/9 glycoforms of recombinant human acid α-glucosidase (rhGAA), which is a therapeutic enzyme for Pompe disease. "
2.	Bone Fractures (Bone Fracture) 09/29/2020 - "We show that treatment of MSCs with Kifunensine increases cell migration toward bone fracture sites after percutaneous injection, and toward lungs after intravenous injection. "
3.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 06/10/2020 - "Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. "
4.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2019 - "Functional consequences of mannosidase inhibition using kifunensine and MAN1A1 knock out were investigated in ovarian cancer cells in vitro. "
5.	Neoplasms (Cancer) 05/01/1987 - "FR-900494 is a new type of immunoactive substances produced by an actinomycete named Kitasatosporia kifunense sp. nov. FR-900494 exhibits a competitive action against immunosuppressive factor produced in the serum of tumor bearing mice and has the capacity to restore the depression of lymphocytes."

Related Drugs and Biologics

1.	Mannosidases
2.	Swainsonine
3.	Glucosidases
4.	Enzymes
5.	Acids
6.	human GAA protein (Myozyme)
7.	Tunicamycin
8.	Mannose (D-Mannose)
9.	Glycoproteins (Glycoprotein)
10.	Rituximab (Mabthera)

Related Therapies and Procedures

1.	Intravenous Injections