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losigame (A033)

tetronic acid derivative
Also Known As:
A033; losigamone; AO-33; (5RS)-(alphaSR)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2(5H)-furanone; 5-(2-chlorophenylhydroxymethyl)-4-methoxy-2-(5H)-furanone; A 033; A-033; ADD137022
Networked: 14 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Luo, Hongye: 4 articles (12/2019 - 06/2012)
2. Luo, Man: 4 articles (12/2019 - 06/2012)
3. Wang, Jin: 4 articles (12/2019 - 06/2012)
4. Xiao, Yousheng: 4 articles (12/2019 - 06/2012)
5. Maguire, Melissa: 2 articles (05/2011 - 06/2010)
6. Marson, Anthony G: 2 articles (05/2011 - 06/2010)
7. Ramaratnam, Sridharan: 2 articles (05/2011 - 06/2010)
8. Losigamone Study Group: 2 articles (08/2003 - 04/2001)
9. Dienel, A: 2 articles (10/2001 - 04/2001)
10. Chen, Hongchang: 1 article (12/2019)

Related Diseases

1. Partial Epilepsies (Epilepsy, Partial)
2. Seizures (Absence Seizure)
3. Epilepsy (Aura)
09/01/2003 - "Perspectives of losigamone in epilepsy treatment."
10/01/1999 - "In this review, we consider the possible physiological targets for anti-epileptic drugs, the animal models of epilepsy, problems with clinical trials and ten promising anti-epileptic drugs in development (AWD 131-138, DP16 (DP-VPA), ganaxolone, levetiracetam, losigamone, pregabalin, remacemide, retigabine, rufinamide and soretolide). "
05/06/2011 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."
06/28/2010 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."
4. Temporal Lobe Epilepsy
05/06/2011 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."
06/28/2010 - "In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or generalised epilepsy who are in remission; behavioural and psychological treatments for partial or generalised epilepsy (biofeedback, cognitive behavioural therapy (CBT), educational programmes, family counselling, relaxation therapy (alone or plus behavioural modification therapy, yoga); and surgery for drug-resistant temporal lobe epilepsy ( lesionectomy, temporal lobectomy, vagus nerve stimulation as adjunctive therapy)."
5. Dizziness (Lightheadedness)

Related Drugs and Biologics

1. Anticonvulsants (Antiepileptic Drugs)
2. Levetiracetam (Keppra)
3. ezogabine (retigabine)
4. Vigabatrin
5. Valproic Acid (Depakote)
6. Phenytoin (Dilantin)
7. Phenobarbital (Luminal)
8. Carbamazepine (Tegretol)
9. Allopurinol (Remid)
10. Lacosamide

Related Therapies and Procedures

1. Therapeutics
2. Vagus Nerve Stimulation
3. Relaxation Therapy (Relaxation Technique)
4. Psychology Biofeedback (Biofeedback)