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acetylaminophenylarsine oxide

Also Known As:

APAO

Networked: 12 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lam, Dennis S C: 2 articles (07/2020 - 07/2012)
2.	Tham, Clement C Y: 2 articles (07/2020 - 07/2012)
3.	Alhonen, Leena: 2 articles (01/2018 - 09/2012)
4.	Hyvönen, Mervi T: 2 articles (01/2018 - 10/2016)
5.	Keinänen, Tuomo A: 2 articles (01/2018 - 10/2016)
6.	Fan, Weiyu: 1 article (05/2021)
7.	Pei, Xiaoguang: 1 article (05/2021)
8.	Huang, Suber S: 1 article (07/2020)
9.	Ko, Chung-Nga: 1 article (07/2020)
10.	Lai, Kenny H W: 1 article (07/2020)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2018 - "Surprisingly, analogue deuteration did not markedly alter the anti-proliferative efficacy of the drugs in DU145 prostate cancer cells, while in mouse embryonic fibroblasts, which had higher basal APAO and SMOX activities, moderate effect was observed. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2016 - "Therefore, SMO and APAO stimulation might be useful biomarkers for the efficacy of endoxifen treatment of breast cancer."
3.	Neoplasms (Cancer) 06/20/2009 - "High expression of APAO can greatly decrease the sensitivity of tumor cells to the specific polyamine analogues by detoxifying those analogues and prevent analogue induced apoptosis." 06/20/2009 - "Recent studies have demonstrated in vitro that some antitumor polyamine analogues could be used as substrates and oxidized by purified recombinant human N(1)-acetylpolyamine oxidase (APAO, an enzyme that catabolizes natural polyamines), indicating a potential role of APAO in determining the sensitivity of cancer cells to specific antitumor analogues. " 12/01/2012 - "The use of APAO-FITC in the identification of different protein and cell targets, as well as in in vivo biodistribution studies, conformational studies of arsenic-binding proteins, and studies for the design of drug delivery systems for arsenic anti-cancer therapies, is highly promising."
4.	Lung Neoplasms (Lung Cancer) 06/20/2009 - "A clone with high expression of APAO was obtained by transfecting A549 lung cancer cell line with pcDNA3.1/APAO plasmid and selecting with quantitative realtime PCR and APAO activity assay. " 06/20/2009 - "This study evaluated, in vivo, the effect of APAO on cytotoxicity of antitumor polyamine analogue, N(1)-cyclopropylmethyl-N(11)-ethylnorspermine (CPENS) and its mechanism when highly expressed in human lung cancer line A549. "
5.	Carcinogenesis 09/01/2012 - "Accumulation of putrescine is indicating for accelerated degradation of polyamines by SSAT - acetylpolyamine oxidase (APAO) pathway generating toxic products that promote carcinogenesis, whereas accelerated polyamine synthesis via activation of ODC is favorable for proliferation of cells including those sub-lethally damaged by oxidative stress."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	4-hydroxy-N-desmethyltamoxifen
3.	Proteins (Proteins, Gene)
4.	Polyamines
5.	Arsenic
6.	Fluorescein-5-isothiocyanate (FITC)
7.	Enzymes
8.	Carrier Proteins (Binding Protein)
9.	human N(1)-acetylpolyamine oxidase
10.	Adiponectin

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Thrombectomy
4.	Osteotomy