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A 68930

D-1 dopamine receptor agonist

Also Known As:

1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran; 5,6-dihydroxy-3-phenyl-1-aminomethylisochroman; A 70108; A 70360; A-68930; A-70108; A-70360; A68930; A70108; A70360

Networked: 11 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Pyrans: 5
  - Benzopyrans: 11
    - Chromans: 1
      - A 68930: 11
- 2-Ring Heterocyclic Compounds
  - Benzopyrans: 11
    - Chromans: 1
      - A 68930: 11

Experts

1.	Huang, Li-Tung: 2 articles (03/2007 - 11/2004)
2.	Yang, San-Nan: 2 articles (03/2007 - 11/2004)
3.	Chen, Wu-Fu: 2 articles (03/2007 - 11/2004)
4.	Yang, Chin-Hwa: 2 articles (03/2007 - 11/2004)
5.	Tighe, Orna: 2 articles (02/2006 - 03/2005)
6.	Waddington, John L: 2 articles (02/2006 - 03/2005)
7.	Croke, David T: 2 articles (02/2006 - 03/2005)
8.	O'Sullivan, Gerard J: 2 articles (02/2006 - 03/2005)
9.	Kinsella, Anthony: 2 articles (02/2006 - 03/2005)
10.	Egerland, Ute: 1 article (05/2012)

Related Diseases

1.	Anoxia (Hypoxia) 03/01/2007 - "In addition, activation of the D1/D5R via A68930 (a selective, CNS-permeable agonist of D1/D5Rs) administration (2 mg/kg/day, P17-23 inclusively) markedly attenuated the hypoxia-induced deleterious effects, suggesting an effective therapeutic efficacy for A68930. " 11/16/2004 - "Impaired SynGAP expression and long-term spatial learning and memory in hippocampal CA1 area from rats previously exposed to perinatal hypoxia-induced insults: beneficial effects of A68930." 11/16/2004 - "We also evaluated the therapeutic efficacy of A68930, a selective agonist of dopamine D1/D5 receptors, on perinatal hypoxia insults. "
2.	Seizures (Seizure) 03/15/2005 - "Though programmed grooming syntax and episodic seizure activity induced by A 68930 and SK&F 83822 were unaltered, grooming induced by SK&F 83959 was reduced in D(5) mutants. " 08/01/1992 - "However, unlike SKF-38393, a high dose of A-68930 produced seizure activity and markedly desensitized D1-dopamine receptor activation for up to 3 days after administration. " 02/01/2006 - "Induction of grooming and, at higher doses, seizures by A 68930, which stimulates both adenylyl cyclase (AC) and phospholipase C (PLC), were unaltered in congenic D4 knockouts. "
3.	Hypothermia 01/19/1998 - "The dose-dependent hypothermia produced by 7-OH-DPAT (0.06-1.00 micromol kg-1 s.c.) was also augmented in an additive manner by pretreatment with A 68930 (0.9 micromol kg-1 s.c.). " 01/19/1998 - "The dose-dependent hypothermia produced by the dopamine D1 receptor agonist A 68930 (0.9-15.0 micromol kg-1, s.c.), was augmented in an additive manner by pretreatment with the dopamine D2/3 receptor agonist 7-OH-DPAT (0.06 micromol kg-1, s.c.). " 02/21/1994 - "Clozapine did not antagonize hypothermia produced by selective dopamine D1 and D2 receptor agonists (A 68930 and quinpirole), the alpha 2-adrenoceptor agonist clonidine, the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) or the muscarinic M1 receptor agonist oxotremorine. "
4.	Tachycardia (Tachyarrhythmias) 02/01/1994 - "Intravenous infusion of A-68930, fenoldopam or DA produced a fall in renal vascular resistance and a rise in renal blood flow (RBF), with hypotension and tachycardia. "
5.	Stomach Ulcer (Gastric Ulcer) 09/15/2010 - "Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats." 09/15/2010 - "The dopamine D(1) receptor agonist (A 68930) and antagonist (SCH 23390), and D(2) receptor agonist (quinpirole) and antagonist (sulpiride) were used to evaluate their effects on acute stress (single immobilization for 150 min) and chronic unpredictable stress (two different types of stressors for 7 days) induced gastric ulcers in rats. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Quinpirole
3.	Clozapine (Clozaril)
4.	SCH 23390
5.	5-HT1A Serotonin Receptor
6.	Muscarinic M1 Receptor
7.	Fenoldopam (Corlopam)
8.	Dopamine Agonists (Dopamine Agonist)
9.	Dopamine D1 Receptors (Dopamine D1 Receptor)
10.	2,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)

Related Therapies and Procedures

1.	Intravenous Infusions