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igmesine

Also Known As:

JO 1784; JO-1784; cinnamyl-1-phenyl-1-N-methyl-N-cyclopropylene

Networked: 11 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopropanes: 9
        igmesine: 11
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - igmesine: 11

Experts

1.	Maurice, Tangui: 2 articles (06/2006 - 05/2002)
2.	Borgese, F: 1 article (01/2017)
3.	Chamorey, E: 1 article (01/2017)
4.	Chantôme, A: 1 article (01/2017)
5.	Clarysse, L: 1 article (01/2017)
6.	Crottès, D: 1 article (01/2017)
7.	Fourbon, Y: 1 article (01/2017)
8.	Fromont, G: 1 article (01/2017)
9.	Girault, A: 1 article (01/2017)
10.	Gueguinou, M: 1 article (01/2017)

Related Diseases

1.	Diarrhea 11/01/2004 - "The Sigma-1-selective igmesine (200 mg) showed good results in a phase-1-model of functional diarrhea and some promising results in depressed patients. " 09/01/1998 - "Igmesine, a final sigma ligand, has been shown to inhibit intestinal secretion and diarrhea in animal models. " 11/01/2004 - "So far, sigma-ligands have been investigated for several indications in human studies in functional diarrhea as a model of somatoform disorder (igmesine), depression (igmesine, opipramol), anxiety (opipramol and--in animal models--siramisine), schizophrenia (panamasine, SL 82.0715, rimcazole, DuP 734, BMY 14 802), and somatoform disorders (opipramol). "
2.	Amnesia (Dissociative Amnesia) 04/19/1991 - "In the present study the effects of JO 1784 on experimental induced amnesia were investigated using one trial passive avoidance task in rats. " 05/01/2002 - "The behavioural efficacy of the selective sigma( 1) agonists igmesine and PRE-084 -- reversion of the scopolamine-induced amnesia in the passive avoidance test; diminution of the immobility duration in the forced swimming test -- were significantly higher in C57BL/6 than in Swiss. " 04/19/1991 - "Of the drugs investigated JO 1784 (0.25, 1.0, 4.0 and 16.0 mg/kg i.p.), (+)-3-PPP (0.25, 1.0 and 4.0 mg/kg i.p.), DTG (1.0, 4.0 and 8.0 mg/kg) and piracetam significantly reversed scopolamine induced amnesia on day 3 (T3). "
3.	Duodenal Ulcer (Curling's Ulcer) 02/01/1993 - "JO 1784 elicited a potent protection against duodenal ulcers but had a weaker protective effect on any of the gastric ulceration models tested. "
4.	Somatoform Disorders (Somatoform Disorder) 11/01/2004 - "So far, sigma-ligands have been investigated for several indications in human studies in functional diarrhea as a model of somatoform disorder (igmesine), depression (igmesine, opipramol), anxiety (opipramol and--in animal models--siramisine), schizophrenia (panamasine, SL 82.0715, rimcazole, DuP 734, BMY 14 802), and somatoform disorders (opipramol). "
5.	Schizophrenia (Dementia Praecox) 11/01/2004 - "So far, sigma-ligands have been investigated for several indications in human studies in functional diarrhea as a model of somatoform disorder (igmesine), depression (igmesine, opipramol), anxiety (opipramol and--in animal models--siramisine), schizophrenia (panamasine, SL 82.0715, rimcazole, DuP 734, BMY 14 802), and somatoform disorders (opipramol). "

Related Drugs and Biologics

1.	Scopolamine (Hyoscine)
2.	2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylate
3.	Ligands
4.	Tacrine (Cognex)
5.	Opipramol
6.	Galantamine (Galanthamine)
7.	Cholinesterase Inhibitors (Anticholinesterases)
8.	Donepezil (Aricept)
9.	Rivastigmine (Exelon)
10.	DuP 734