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4-hydroxy-equilenin

structure given in first source; is the major catechol metabolite of the equine estrogens EQUILENIN and EQUILIN; induces DNA damage

Also Known As:

4-hydroxyequilenin

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Ketosteroids: 23
      - 17-Ketosteroids: 611
        Equilenin: 7
        4-hydroxy-equilenin: 6
    - Estranes
      - Estrenes
        Equilenin: 7
        4-hydroxy-equilenin: 6
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Equilenin: 7
        4-hydroxy-equilenin: 6

Experts

1.	Bolton, Judy L: 2 articles (10/2007 - 12/2004)
2.	Chang, Minsun: 2 articles (10/2007 - 12/2004)
3.	Bolton, J L: 2 articles (06/2001 - 05/2000)
4.	Hua, Y: 2 articles (06/2001 - 05/2000)
5.	Zhang, F: 2 articles (06/2001 - 05/2000)
6.	van Breemen, R B: 2 articles (06/2001 - 05/2000)
7.	Kastrati, Irida: 1 article (10/2007)
8.	Overk, Cassia R: 1 article (10/2007)
9.	Peng, Kuan-wei: 1 article (10/2007)
10.	Qin, Zhi-Hui: 1 article (10/2007)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 05/01/2000 - "A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines." 06/01/2001 - "Finally, preliminary studies conducted with the human breast tumor S-30 cell lines demonstrated that the catechol metabolites of 8,9-dehydroestrone were much less toxic than 4-hydroxyequilenin (20-40-fold). " 12/30/2004 - "4-Hydroxyequilenin (4-OHEN), a major catechol metabolite of equine estrogens present in Premarin, an estrogen replacement formulation, has been shown to induce apoptosis and DNA damage in human breast cancer cells. " 02/01/1999 - "Finally, preliminary studies conducted with the human breast tumor cell line MCF-7 demonstrated that the cytotoxic effects of the catechol estrogens from estrone, equilin, and 2-hydroxyequilenin were similar, whereas 4-hydroxyequilenin was a much more potent cytotoxin ( approximately 30-fold). "
2.	Carcinogenesis 10/01/2007 - "4-MeOEN results from O-methylation of 4-hydroxyequilenin, a major catechol metabolite of the equine estrogens present in hormone replacement therapeutics, which causes DNA damage via quinone formation, raising the possibility of synergistic hormonal and chemical carcinogenesis. "
3.	Melanoma (Melanoma, Malignant) 05/01/1997 - "Finally, we have compared the cytotoxicity of 4-hydroxyequilenin with that of the estrone catechols in human melanoma cells. "

Related Drugs and Biologics

1.	catechol (pyrocatechol)
2.	Estrone
3.	Equilin
4.	Cytotoxins (Cytolysins)
5.	Catechol Estrogens
6.	3- hydroxy- 1,3,5(10),8,9- estratetraen- 17- one
7.	2-hydroxyequilenin
8.	Estrogens (Estrogen)
9.	Hormones (Hormone)
10.	Conjugated (USP) Estrogens (Premarin)

Related Therapies and Procedures

1.	Estrogen Replacement Therapy
2.	Therapeutics