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KB 5492
Also Known As:
1-(3,4,5-trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine; KB-5492
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperazines: 26
KB 5492: 7
Related Diseases
1.
Ulcer
12/01/1991 - "
These results indicate that KB-5492 has potent and broad anti-ulcer properties, which are probably exerted by its enhancement of gastric mucosal defensive factors through increasing gastric mucosal blood flow and/or retaining gastric mucus, and not by its inhibition of gastric acid secretion.
"
08/11/1994 - "
These findings suggest that KB-5492 is a unique anti-ulcer agent which binds to sigma receptors in porcine gastric fundic mucosa.
"
08/11/1994 - "
Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa.
"
05/02/1994 - "
Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain.
"
03/01/1994 - "
In contrast, anti-ulcer doses of KB-5492, but not cimetidine, increased duodenal HCO3- secretion in normal anesthetized rats.
"
2.
Stomach Ulcer (Gastric Ulcer)
12/01/1991 - "
In addition, KB-5492, administered orally at 25 and 50 mg/kg twice daily for 10 consecutive days, significantly accelerated the healing of acetic acid-induced gastric ulcers more potently than teprenone and cimetidine.
"
3.
Duodenal Ulcer (Curling's Ulcer)
03/01/1994 - "
These findings suggest that KB-5492 prevents cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion, whereas cimetidine does so by inhibiting cysteamine-induced gastric acid hypersecretion.
"
03/01/1994 - "
Both KB-5492, a new anti-ulcer agent, and cimetidine, administered orally at 25-200 mg/kg, dose-dependently prevented cysteamine (400 mg/kg, s.c.)-induced duodenal ulcers in rats with ED50 values of 63 and 40 mg/kg, respectively.
"
Related Drugs and Biologics
1.
sigma Receptors (sigma Receptor)
2.
Aspirin (Acetylsalicylic Acid)
3.
Cimetidine (Biomet)
4.
Ethanol (Ethyl Alcohol)
5.
Guanidine (Guanidine Nitrate)
6.
Acetic Acid (Vinegar)
7.
Dinoprostone (PGE2)
8.
Prednisolone (Predate)
9.
Ligands
10.
Indomethacin (Indometacin)