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3- (1,2,5,6- tetrahydropyrid- 4- yl)pyrrolo(3,2- b)pyrid- 5- one

serotonin agonist; structure given in first source

Also Known As:

CP 93129; CP-93,129

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one: 4
  - Pyridines: 88
    - 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one: 4

Experts

1.	Lucion, Aldo Bolten: 2 articles (02/2011 - 12/2008)
2.	Miczek, Klaus A: 2 articles (02/2011 - 12/2008)
3.	de Almeida, Rosa Maria Martins: 2 articles (02/2011 - 12/2008)
4.	da Veiga, Caroline Perinazzo: 1 article (02/2011)
5.	Guptarak, Jutatip: 1 article (12/2010)
6.	Hiegel, Cindy: 1 article (12/2010)
7.	Uphouse, Lynda: 1 article (12/2010)
8.	Centenaro, Lígia Aline: 1 article (12/2008)
9.	Vieira, Karin: 1 article (12/2008)
10.	Zimmermann, Nicolle: 1 article (12/2008)

Related Diseases

1.	Bites and Stings (Sting) 02/01/2011 - "By contrast, CP-93,129 (1.0 μg) microinjected into VO PFC decreased the number of attack bites and lateral threats. " 12/01/2008 - "The lowest dose of CP-93,129 (0.1 microg) also decreased the number of attack bites and lateral threats. "
2.	Pain (Aches) 06/01/1992 - "Pretreatment with sumatriptan (720 nmol kg-1 x 2, i.v.) did not block c-fos expression in trigeminal nucleus caudalis following formalin application to the nasal mucosa.6. Drug-induced blockade may be mediated by an action on primary afferent (trigeminovascular) fibres in as much as CP-93,129 (460 nmol kg-' x 2, i.v.) did not reduce the number of expressing cells within the trigeminal nucleus caudalis following blood instillation in rats treated as neonates with capsaicin.7. We infer from these results that the analgesic actions of agonists at 5-HTB receptors (the receptor subtype analogous to 5-HTID in man) need not depend upon the presence of vasodilatation and, that 5-HTID receptor-mediated blockade of neurotransmission contributes significantly to the analgesic effects of these drugs in headache.8. Based on the demonstrated effects of 5-HTB/D agonists against the actions of two chemicallyunrelated meningeal stimulants, we suggest that treatment with 5-HTID agonists may be useful for the alleviation of pain in other headache conditions associated with meningeal irritation. "
3.	Lordosis 12/01/2010 - "EO rats showed a transient decline in lordosis behavior following infusion with the saline vehicle and this was amplified by CP 93129. "
4.	Headache (Headaches) 06/01/1992 - "Pretreatment with sumatriptan (720 nmol kg-1 x 2, i.v.) did not block c-fos expression in trigeminal nucleus caudalis following formalin application to the nasal mucosa.6. Drug-induced blockade may be mediated by an action on primary afferent (trigeminovascular) fibres in as much as CP-93,129 (460 nmol kg-' x 2, i.v.) did not reduce the number of expressing cells within the trigeminal nucleus caudalis following blood instillation in rats treated as neonates with capsaicin.7. We infer from these results that the analgesic actions of agonists at 5-HTB receptors (the receptor subtype analogous to 5-HTID in man) need not depend upon the presence of vasodilatation and, that 5-HTID receptor-mediated blockade of neurotransmission contributes significantly to the analgesic effects of these drugs in headache.8. Based on the demonstrated effects of 5-HTB/D agonists against the actions of two chemicallyunrelated meningeal stimulants, we suggest that treatment with 5-HTID agonists may be useful for the alleviation of pain in other headache conditions associated with meningeal irritation. "

Related Drugs and Biologics

1.	Sumatriptan (Imigran)
2.	Formaldehyde (Formol)
3.	Capsaicin (Zostrix)
4.	Analgesics (Analgesic Drugs)
5.	4-trifluoromethylsalicylic acid (HTB)