3- (3,5- dichlorophenyl)- 1- methyl- 2,5- pyrrolidinedione (DPMS)

01/01/2022 - "This study demonstrated that the baseline fALFF features have good potential for predicting individualized treatment response of taVNS in MWoA patients, and those weight brain areas are mainly involved in the thalamocortical (TC) circuits, default mode network (DMN), and descending pain modulation system (DPMS). "
01/01/2017 - "The objective of this imaging genetics study was therefore to explore if differences in functional connectivity (FC) of the DPMS between the OPRM1 A118G polymorphisms could provide a possible explanation for the differences in pain experience. "
11/11/2023 - "There was a significant age by gender interaction during moderate pain in the right ACC and bilateral insula, such that, males had a stronger positive relationship between DPMS response and age compared to females in these regions. "
11/11/2023 - "Using functional MRI, we examined brain responses in the descending pain modulatory system (DPMS, specifically, dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex (ACC), insula, hypothalamus, amygdala, and periaqueductal gray (PAG), during an evoked pain task. "
10/10/2023 - "Our findings significantly revise current models of the DPMS and establish a novel supraspinal antinociceptive pathway that may contribute to multiple forms of descending pain modulation."

09/02/2017 - "Thus, understanding the role(s) of brain DPMs in this dementia subtype may provide novel insight on the disease pathogenesis and may aid on the development of novel diagnostic and therapeutic tools. "
01/01/2022 - "In the Diagnostic and Patient Management Study (DPMS), 844 participants from eight centres across three clinical subgroups (245 subjective cognitive decline, 342 mild cognitive impairment, and 258 dementia) were included. "
11/03/2016 - "Future studies will further elucidate the mechanisms underlying dementia pathogenesis via the quantitative profiling of the human brain proteome and associated DPMs in distinct phases and subtypes of disease. "
09/02/2017 - "Brain degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer's disease with cerebrovascular disease (AD + CVD) is the most prevalent form of dementia in the elder population. "
01/01/2019 - "Degenerative protein modifications (DPMs) have been strongly implicated in the molecular pathogenesis of several age-related diseases affecting the CVS and CNS, including atherosclerosis, heart disease, dementia syndromes, and stroke. "

02/03/2016 - "Impaired DPMS in migraine patients can be normalized after effective treatment. "
02/03/2016 - "Impairment of the DPMS is involved in the neural pathophysiology of migraines. "
01/01/2021 - "The aim of this study is to investigate the modulation effect of taVNS frequency on the descending pain modulation system (DPMS) in patients with migraine. "
01/01/2021 - "For studies that performed a correlation analysis between functional brain changes and sustained clinical efficacy, the prophylactic effect of acupuncture on migraine might be through regulation of the visual network, default mode network (DMN), sensory motor network, frontoparietal network (FPN), limbic system, and/or descending pain modulatory system (DPMS). "

01/01/2023 - "This prospective, multicenter study was conducted as part of The Amyloid Imaging to Prevent Alzheimer Disease Diagnostic and Patient Management Study (AMYPAD-DPMS) (recruitment period: from April 2018 to October 2020). "
01/01/2019 - "The Amyloid Imaging to Prevent Alzheimer's Disease-Diagnostic and Patient Management Study (AMYPAD-DPMS) is designed to fill this gap. "
09/02/2017 - "Brain degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer's disease with cerebrovascular disease (AD + CVD) is the most prevalent form of dementia in the elder population. "

01/01/2021 - "Male gender (hazard ratio [HR] = 4.597), two or more DPMs (HR = 8.071), and shorter time interval between two cancers occurrences (HR = 7.101) were significantly risk factors for DPM-related death. "
01/01/2018 - "Dynamic Function of DPMS Is Essential for Angiogenesis and Cancer Progression."
04/01/2008 - "We have evaluated the involvement of DPMS in angiogenesis, an essential physiological event during the growth of breast and other solid tumors. "
11/23/2023 - "Clinical suspicion of melanoma is common in combined DPMs, but the malignant progression is infrequent in tumors lacking high-grade atypia or proliferation. "
01/01/2020 - "Over-expressions of DPMS were discovered to be dramatically associated with clinical cancer stages and pathological tumor grades in hepatocellular carcinoma patients. "