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aristololactam BII

isolated from Saururus cernuus; structure given in first source

Also Known As:

cepharanone B

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        Aristolochic Acids: 79
        aristololactam BII: 1
- Nitro Compounds: 66
  - Aristolochic Acids: 79
    - aristololactam BII: 1
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - Aristolochic Acids: 79
      - aristololactam BII: 1

Experts

1.	Ayuso, M J: 1 article (09/2001)
2.	Bermejo, A: 1 article (09/2001)
3.	Cortes, D: 1 article (09/2001)
4.	López-Lázaro, M: 1 article (09/2001)
5.	Martín-Cordero, C: 1 article (09/2001)

Related Diseases

1.

Neoplasms (Cancer)

09/01/2001 - "The six compounds showed cytotoxic activity, with cepharanone B being the most cytotoxic one, even more than the antineoplastic agent etoposide on two cancer cell lines, although it is the only one that does not act as a DNA topoisomerase poison. "
09/01/2001 - "In the search for cytotoxic natural products as DNA topoisomerase poisons, we have assessed six annonaceus compounds (the acetogenins annonacin and rolliniastatin-1, the styryl-lactones etharversin and altholactone and the alkaloids thaligrisine and cepharanone-B) for cytotoxic activity against three human cancer cell lines and then we evaluated these compounds as DNA topoisomerase poisons. "

Related Drugs and Biologics

1.	Acetogenins
2.	A-Form DNA (A-DNA)
3.	Poisons
4.	Lactones
5.	Etoposide (VP 16)
6.	Type I DNA Topoisomerases (Topoisomerase I)
7.	Antineoplastic Agents (Antineoplastics)
8.	Alkaloids
9.	altholactone
10.	thaligrisine