antiflammin P1

nonapeptide fragment of uteroglobin has no phospholipase A2 inhibitory & anti-inflammatory activity; RN given refers to all (L)-isomer

Also Known As:

MQMKKVLDS; Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser; antiflamin 1; antiflammin 1; methionyl-glutaminyl-methionyl-lysyl-lysyl-valyl-leucyl-aspartyl-serine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Inflammation (Inflammations) 08/01/1997 - "Antiflammin 1 peptide delivered non-invasively by iontophoresis reduces irritant-induced inflammation in vivo." 08/01/1997 - "Lesion formation was also reduced in the presence of antiflammin 1. In vitro flux across hairless guinea pig skin demonstrated no significant differences in flux of the irritant compound in the presence or absence of antiflammin 1. In vivo generation and efflux of the inflammation mediator Prostaglandin E2 increased during 24-h application of irritant and was unchanged in the presence of antiflammin 1. This result is discussed with respect to recent evidence that antiflammins may act on the lipo-oxygenase pathway. "
2.	Erythema 08/01/1997 - "Antiflammin 1 delivered by iontophoresis significantly decreased, but did not eliminate, the erythema associated with co-delivery of an irritating drug compound. "