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5- N- acetyl- 9- (4- azidosalicoylamido)- 2- deoxy- 2,3- didehydroneuraminic acid
structure given in first source
Also Known As:
5-acetamido-2,6-anhydro-9-(4'-azido-2'-hydroxybenzamido)-3,5,9-trideoxygalacto-nonuloso-2-enonic acid; ASA-Neu5Ac2en; NeuAc2en
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Nitrogen Compounds: 67
Azides: 384
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Organic Chemicals: 133
Carboxylic Acids: 973
Hydroxy Acids: 94
Sugar Acids: 4
Neuraminic Acids: 8
Sialic Acids: 594
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Acyclic Acids
Sugar Acids: 4
Neuraminic Acids: 8
Sialic Acids: 594
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Azides: 384
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Carbohydrates: 22023
Amino Sugars: 110
Neuraminic Acids: 8
Sialic Acids: 594
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Sugar Acids: 4
Neuraminic Acids: 8
Sialic Acids: 594
5-N-acetyl-9-(4-azidosalicoylamido)-2-deoxy-2,3-didehydroneuraminic acid: 2
Experts
1.
Cantz, M
: 1 article (01/2001)
2.
Kopitz, J
: 1 article (01/2001)
3.
Schuhmann, V
: 1 article (01/2001)
4.
von Reitzenstein, C
: 1 article (01/2001)
Related Diseases
1.
Neuroblastoma
12/01/1991 - "
Effects of GM1 and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NeuAc2en) on neuroblastoma (Neuro 2a) and human glioma cells (U1242 MG).
"
01/01/2001 - "
The presence of the inhibitor NeuAc2en led to a profound decrease in the amount of the differentiation marker 200 kDa/70 kDa neurofilaments and an increase in cell proliferation in the cholinergic SK-N-MC and mixed cholinergic/adrenergic SK-N-FI and SK-N-DZ neuroblastoma lines, but had little or no effect in the human adrenergic SK-N-SH and SK-N-AS and the adrenergic/cholinergic PC12 cells from rat.
"
12/01/1991 - "
Growth of neuroblastoma (Neuro 2a) cells in medium containing fetal bovine serum was inhibited in a dose-dependent fashion by both exogenous GM1 ganglioside and NeuAc2en, an inhibitor of sialidase activity.
"
2.
Glioma (Gliomas)
12/01/1991 - "
In contrast, growth of glioma cells (U-1242 MG) was not affected by exogenous GM1 or NeuAc2en in the presence of as little as 1% calf serum.
"
12/01/1991 - "
Effects of GM1 and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (NeuAc2en) on neuroblastoma (Neuro 2a) and human glioma cells (U1242 MG).
"
Related Drugs and Biologics
1.
Cholinergic Agents (Cholinergics)
2.
Adrenergic Agents (Adrenergic Drugs)
3.
Bovine Serum Albumin
4.
Neuraminidase (Sialidase)
5.
G(M1) Ganglioside
6.
Differentiation Antigens
7.
2-deoxy-2,3-dehydro-N-acetylneuraminic acid