albolabrin
RGD-containing peptide; has homology with the RGDS domain of fibrinogen & von Willebrand factor; amino acid sequence given in first source
Also Known As:
Albolabrin
Networked: 4
relevant articles (1 outcomes,
0 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Related Diseases
1. | Melanoma (Melanoma, Malignant)
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2. | Neoplasms (Cancer)
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3. | Neoplasm Metastasis (Metastasis)
09/01/1991
- " In an in vivo experimental metastasis system, albolabrin at a concentration of 300-600 nM inhibited C57BL/6 mouse lung colonization by tail vein-injected mouse melanoma cells and was at least 2000 times more active than RGDS in this assay. " 09/01/1991
- " We propose that albolabrin inhibits tumor cell metastasis by inhibiting integrin-mediated attachment of melanoma cells to RGD-containing components of the extracellular matrix in the mouse lung." 09/01/1991
- " Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, an RGD-containing peptide isolated from the venom of Trimeresurus albolabris." 01/01/1995
- " Four disintegrins, eristostatin, albolabrin, barbourin and echistatin, injected IV into C57BL/6 mice in combination with B16F10 murine melanoma cells, inhibited formation of experimental lung metastases with ID50s of 0.05, 1.0, 0.9, and 3.7 mumoles per mouse, respectively. "
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4. | Sudden Death
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