HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

N,N'- bis(4- hydroxycyclohexyl)- N'- nitrosourea

RN given refers to (trans)-isomer; RN for cpd without isomeric designation not avail 7/90; has carbamoylating activity

Also Known As:

BHCNU

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - N,N'-bis(4-hydroxycyclohexyl)-N'-nitrosourea: 2
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - N,N'-bis(4-hydroxycyclohexyl)-N'-nitrosourea: 2

Related Diseases

1.	Leukemia 07/01/1990 - "Treatment of K562 human leukemia cells with 15 microM BHCNU for 1 h resulted in depletion of glutathione to 40% of control values, without significant reduction of cell viability. "
2.	Neoplasms (Cancer) 10/01/1985 - "Early (2-4) passage cultures from these tumors were treated in vitro with model drugs for alkylation (BCNU, CHLZ (2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose), ENU (N-ethyl-N-nitrosourea), cross-linking (BCNU, CHLZ) and carbamoylation BHCNU (1,3 bis (trans-4-hydrocyclohexyl)-1-nitrosourea): dose-schedules were compatible with clinically achievable levels. "
3.	Glioma (Gliomas) 10/01/1985 - "However, in pediatric gliomas the levels of cell kill after treatment with the purely carbamoylating agent BHCNU, even at the highest doses tested, were lower than expected."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Ethylnitrosourea (N-Ethyl-N-nitrosourea)
3.	Carmustine (FIVB)
4.	2- ((3- chloroethyl)- 3- nitrosoureido)glucopyranose

Related Therapies and Procedures

1.	Aftercare (After-Treatment)