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EM 139

EM-170 is the (17'alpha)-isomer

Also Known As:

EM 170; EM-139; EM-170; N-n-butyl-N-methyl-11-(16'alpha-chloro-3',17'beta-dihydroxyestra-1',3',5'(10')-trien-7'alpha-yl)undecanamide

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        Estradiol: 14115
        EM 139: 5
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Estradiol: 14115
        EM 139: 5

Related Diseases

1.	Carcinoma (Carcinomatosis) 03/01/1995 - "In this study, we examined the activity of the new steroidal antiestrogen EM-170 (N-n-butyl, N-methyl-11-(16' alpha-chloro-3',17' alpha-dihydroxy-estra-1',3',5'-(10')-trien-7' alpha-yl) undecanamide) on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma stimulated by treatment with estrone (E1), a steroid known to play an important role as precursor of 17 beta-estradiol (E2), especially in postmenopausal women. "
2.	Breast Neoplasms (Breast Cancer) 06/15/1991 - "Moreover, the inhibitory effect of DHT can be further increased by addition of the antiestrogen EM-170, thus suggesting the interest of combining these 2 classes of compounds acting, at least partially, through different mechanisms, in order to improve breast cancer therapy in women." 04/15/1994 - "Like the pure steroidal antiestrogen EM-139, these novel nonsteroidal compounds did not exert any stimulatory effect on cell proliferation of (ER+) ZR-75-1 human breast cancer cells and partially reversed the amplitude of the stimulatory effect induced by estradiol on this (ER+) cell line. " 06/15/1991 - "Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice." 06/01/1991 - "We have investigated the effects of the pure antiestrogen EM-139 and the nonaromatizable androgen dihydrotestosterone (DHT) alone or in combination with estradiol (E2) on cell proliferation and cell kinetic parameters in human ZR-75-1 breast cancer cells. "
3.	Neoplasms (Cancer) 03/01/1995 - "At a relatively low dose of 40 micrograms (twice daily), 20 days of treatment with EM-170 reversed by 55% the stimulatory effect of E1 (1.0 micrograms, subcutaneously, twice daily) on tumor growth in OVX animals. " 06/15/1991 - "When the steroidal antiestrogen EM-170 at the dose of 30 micrograms/day was used simultaneously with DHT, tumor area was further reduced from 99.0 +/- 9.5% (DHT alone) to 58.8 +/- 18% when both DHT and EM-170 were administered together for 40 days compared with 169 +/- 22.2% in control E2-stimulated animals. " 03/01/1995 - "Treatment with the antiestrogen EM-170 at a dose of 200 micrograms (twice daily) not only completely reversed the stimulatory effect of E1, but also inhibited tumor growth to 30.5 +/- 9.6%, an effect that is 41% (P < 0.01 vs OVX control) greater than that of ovariectomy alone. "
4.	Prostatic Neoplasms (Prostate Cancer) 10/01/1991 - "Characteristics of the biphasic action of androgens and of the potent antiproliferative effects of the new pure antiestrogen EM-139 on cell cycle kinetic parameters in LNCaP human prostatic cancer cells."

Related Drugs and Biologics

1.	Estrogen Receptor Modulators (Antiestrogen)
2.	Estradiol (Delestrogen)
3.	9,10-Dimethyl-1,2-benzanthracene
4.	Steroids
5.	Estrone
6.	Androgens
7.	Dihydrotestosterone (Androstanolone)

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)