trypanothione synthetase

catalyzes the synthesis of N(1)- and N(8)-glutathionylspermidine and trypanothione from ATP/Mg, glutathione, and spermidine; member of ATP-dependent class of ligases forming an amide linkage

Also Known As:

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fairlamb, Alan H: 2 articles (01/2012 - 12/2009)
2.	Frearson, Julie A: 2 articles (01/2012 - 12/2009)
3.	Gilbert, Ian H: 2 articles (01/2012 - 12/2009)
4.	Harrison, Justin R: 2 articles (01/2012 - 12/2009)
5.	Spinks, Daniel: 2 articles (01/2012 - 12/2009)
6.	Thompson, Stephen: 2 articles (01/2012 - 12/2009)
7.	Torrie, Leah S: 2 articles (01/2012 - 12/2009)
8.	Wyatt, Paul G: 2 articles (01/2012 - 12/2009)
9.	Angiulli, Gabriella: 1 article (01/2015)
10.	Baiocco, Paola: 1 article (01/2015)

Related Diseases

1.	Cysts 09/01/2007 - "histolytica, e) enzymes for the synthesis of trypanothione like the ornithine decarboxylase, spermidine synthase and trypanothione synthetase, f) some of the proteins that assemble the secretory vesicles with the cell membrane, like the synaptobrevins and finally, g) encystment pathways and cyst-wall assembly proteins. " 11/01/2007 - "The study of new targets, such as trypanothione and trypanothione reductase, and the drug effects of selected agents were arranged into six main groups: A) Inhibition of disulfide reducing enzymes by neuroleptics, antimycotics and antibiotics; B) Comparative evaluation of the efficacies of several drugs with antiproliferative activities; C) Inhibition of the enzymes for the synthesis of trypanothione, such as ornithine decarboxylase, spermidine synthase and trypanothione synthetase; D) Inhibition of the glycolytic enzyme PPi-dependent phosphofructokinase (PFK) from Entamoeba and Naegleria by pyrophosphate analogues, different from the host enzyme; E) Inhibition of enzymes secreted by these parasites to invade the human host, for example cysteine proteinases; and F) Inhibition of encystment pathways and cyst-wall assembly proteins."
2.	Leishmaniasis 12/31/2022 - "Trypanothione synthetase (TryS) is an attractive target for the development of drugs against leishmaniasis because it is specific and essential to kinetoplastid parasites. " 01/01/2015 - "arginase (ARG), ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase (SpdS), trypanothione synthetase (TryS or TSA), trypanothione reductase (TryR or TR), tryparedoxin peroxidase (TXNPx), deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are promising targets for the development of new drugs against leishmaniasis. "
3.	Neglected Diseases 01/01/2014 - "Cysteine proteases, trans-sialidase, 1-deoxy-d-xylulose-5-phosphate reductoisomerase, and trypanothione synthetase are presented as additional candidates for application of transition-state analysis with the goal of identifying new leads for the treatment of parasitic neglected tropical diseases. "
4.	African Trypanosomiasis (Nagana) 01/02/2012 - "Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite Trypanosoma brucei, which causes human African trypanosomiasis. "
5.	Trypanosomiasis 12/25/2009 - "Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis."

Related Drugs and Biologics

1.	Spermidine Synthase
2.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
3.	Cysteine Proteases (Cysteine Protease)
4.	Proteins (Proteins, Gene)
5.	Enzymes
6.	trypanothione reductase
7.	trypanothione
8.	Phosphofructokinases
9.	Antipsychotic Agents (Antipsychotics)
10.	Disulfides