Etoposide FDA Link Generic

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Also Known As:

VP 16; Eposide; Lastet; Toposar; Vepesid; Celltop; Eposin; Eto-GRY; Etomedac; Etopos; Etoposide Pierre Fabre; Etoposide Teva; Etoposide, (5S)-Isomer; Etoposide, (5a alpha)-Isomer; Etoposide, (5a alpha,9 alpha)-Isomer; Etoposide, alpha-D-Glucopyranosyl Isomer; Etoposido Ferrer Farma; Exitop; NSC-141540; Onkoposid; Riboposid; VP 16-213; VP-16; Vépéside-Sandoz; Eto GRY; Etoposide, alpha D Glucopyranosyl Isomer; NSC 141540; NSC141540; Teva, Etoposide; VP 16 213; VP 16213; VP16; Vépéside Sandoz; alpha-D-Glucopyranosyl Isomer Etoposide; Demethyl Epipodophyllotoxin Ethylidine Glucoside; Furo(3',4':6,7)naphtho(2,3- d)- 1,3- dioxol- 6(5aH)- one, 9- ((4,6- O- ethylidene- beta- D- glucopyranosyl)oxy)- 5,8,8a,9- tetrahydro- 5- (4- hydroxy- 3,5- dimethoxyphenyl)- , (5R-(5alpha,5abeta,8aalpha,9beta(R*)))-

Pharmalogical Action Categories:

Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        Podophyllotoxin: 562
        Etoposide: 10706
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - Podophyllotoxin: 562
        Etoposide: 10706
Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - Etoposide: 10706

1.	Obstructive Jaundice (Cholestatic Jaundice) 06/01/1990 - "The kinetics and urinary excretion of etoposide and etoposide glucuronide were determined in 11 patients with obstructive jaundice (bilirubin greater than 2.0 mg/dL) and in 23 patients with normal renal and hepatic function. "

etoposide glucuronide

Bio-Agent Context: Research Results

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